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M C Crew

Explore the profile of M C Crew including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 28
Citations 11
Followers 0
Related Specialties
Pharmacology
Biochemistry
Toxicology
Top 10 Co-Authors
L J HAYNES
F J DI CARLO
F J DICARLO
M D Melgar
R L Gala
F J LEINWEBER
C B COUTINHO
J E Young
R C Greenough
S George
Published In
Biochem Pharmacol
Drug Metab Dispos
Xenobiotica
Clin Pharmacol Ther
J Reticuloendothel Soc
Affiliations
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Recent Articles
1.
Metabolism of pentaerythritol trinitrate
DI CARLO F, Crew M, Brusco L, DAVIDSON I
Clin Pharmacol Ther . 1977 Sep; 22(3):309-15. PMID: 560936
The absorption, excretion, and biotransformation of 14C-labeled pentaerythritol (PE) trinitrate was studied in man. The administration of a single sublingual dose was followed by rapid absorption and extensive biotransformation. Six...
2.
3-(Hydroxymethyl)-8-methoxychromone and unconjugated metabolites in rat plasma. Identification of the biologically active species
De Carlo F, Herzig D, Kusner E, Schumann P, Melgar M, George S, et al.
Drug Metab Dispos . 1976 Jul; 4(4):368-71. PMID: 8292
After administering 14C-labeled 3-(hydroxymethyl)-8-methoxychromone to rats by gavage, plasma was found to contain unchanged compound and three unconjugated metabolites. These metabolites were identified as 3-carboxy-8-methoxychromone, 8-methoxychromone, and 2-hydroxy-3-methoxyactophenone. The plasma...
3.
Oxisuran metabolism in pigs
Crew M, Di Carlo F
Drug Metab Dispos . 1976 Mar; 4(2):147-53. PMID: 5259
The fate of oxisuran in the pig was studied with 14C-labeled drug to quantify its biotransformation and disposition. Despite interanimal differences, it was clear that the compound absorbed rapidly and...
4.
Metabolism of 3-(hydroxymethyl)-8-methoxychromone in the rat. II. Classification and identification of urinary drug metabolites
Crew M, Melgar M, George S, Greenough R, Szpiech J, Di Carlo J
Xenobiotica . 1976 Feb; 6(2):89-100. PMID: 1274377
1. Five metabolites were isolated from the urine of dogs dosed with 3-(hydroxymethyl)-8-methoxy[4-14C]chromone. These were identified as 8-methoxychromone, 2-hydroxy-3-methoxyacetophenone, 3-(hydroxymethyl)-8-hydroxychromone, 8-hydroxychromone and 2,3-dihydroxyacetophenone. 2. These compounds were also present in...
5.
Metabolism of 3-(hydroxymethyl)-8-methoxychromone in the rat. I. Absorption, tissue distribution and excretion
Crew M, Szpiech J, DI CARLO F
Xenobiotica . 1976 Feb; 6(2):83-8. PMID: 1274376
1. Two 14C-labelled preparations of 3-(hydroxymethyl)-8-methoxychromone were used to study the absorption, tissue distribution and excretion of isotope after oral administration to rats (20 mg/kg). 2. 14C, presumably from the...
6.
Correlation of analgesia with levels of tilidine and a biologically active metabolite in rat plasma and brain
DUBINSKY B, Crew M, Melgar M, Karpowicz J, DI CARLO F
Biochem Pharmacol . 1975 Jan; 24(2):277-81. PMID: 1111538
No abstract available.
7.
Oxisuran metabolism in the monkey
Crew M, Mitchell L, de la Iglesia F, DI CARLO F
Drug Metab Dispos . 1975 Jan; 3(1):10-4. PMID: 234829
Oxisuran metabolism was studied in the Rhesus monkey in order to assess the suitability of this species as an immunological model for man. The biotransformation pathways observed in the monkey...
8.
Denitration of unconjugated and conjugated pentaerythritol nitrates by rat liver cytosol
Melgar M, LEINWEBER F, Crew M, DI CARLO F
Drug Metab Dispos . 1974 Jan; 2(1):46-52. PMID: 4150133
No abstract available.
9.
Isolation of pentaerythritol nitrates and their glucuronides
LEINWEBER F, Melgar M, Crew M, DI CARLO F
Drug Metab Dispos . 1974 Jan; 2(1):40-5. PMID: 4150132
No abstract available.
10.
Studies on the metabolism in man of oxisuran, a differential immunosuppressive drug
Crew M, Vesell E, PASSANANTI G, Gala R, DI CARLO F
Clin Pharmacol Ther . 1973 Nov; 14(6):1013-21. PMID: 4584148
No abstract available.