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M A Galligan

Explore the profile of M A Galligan including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 17
Citations 521
Followers 0
Related Specialties
Biochemistry
Molecular Biology
Endocrinology
Top 10 Co-Authors
M R Haussler
C A Haussler
G K Whitfield
P W Jurutka
J C Hsieh
S Nakajima
P D Thompson
P N MacDonald
L S Remus
H T Dang
Published In
Mol Endocrinol
J Biol Chem
J Cell Biochem
Biochem Biophys Res Commun
Mol Cell Biol
Affiliations
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Recent Articles
1.
Distinct retinoid X receptor activation function-2 residues mediate transactivation in homodimeric and vitamin D receptor heterodimeric contexts
Thompson P, Remus L, Hsieh J, Jurutka P, Whitfield G, Galligan M, et al.
J Mol Endocrinol . 2001 Sep; 27(2):211-27. PMID: 11564604
The vitamin D receptor (VDR) stimulates transcription as a 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3))-activated heterodimer with retinoid X receptor (RXR). RXR also forms homodimers to mediate 9-cis retinoic acid (9-cis RA)-induced gene...
2.
Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene
Whitfield G, Remus L, Jurutka P, Zitzer H, Oza A, Dang H, et al.
Mol Cell Endocrinol . 2001 May; 177(1-2):145-59. PMID: 11377830
The functional significance of two unlinked human vitamin D receptor (hVDR) gene polymorphisms was evaluated in twenty human fibroblast cell lines. Genotypes at both a Fok I restriction site (F/f)...
3.
The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB
Jurutka P, Remus L, Whitfield G, Thompson P, Hsieh J, Zitzer H, et al.
Mol Endocrinol . 2000 Mar; 14(3):401-20. PMID: 10707958
The human vitamin D receptor (hVDR) is a ligand-regulated transcription factor that mediates the actions of the 1,25-dihydroxyvitamin D3 hormone to effect bone mineral homeostasis. Employing mutational analysis, we characterized...
4.
Biochemical evidence for a 170-kilodalton, AF-2-dependent vitamin D receptor/retinoid X receptor coactivator that is highly expressed in osteoblasts
Jurutka P, Remus L, Whitfield G, Galligan M, Haussler C, Haussler M
Biochem Biophys Res Commun . 2000 Feb; 267(3):813-9. PMID: 10673374
Human vitamin D receptor (hVDR) fused to glutathione S-transferase was utilized to detect a VDR-interacting protein (VIP) of approximately 170 kDa. VIP(170) is expressed in osteoblast-like ROS 17/2.8 cells and,...
5.
Characterization of unique DNA-binding and transcriptional-activation functions in the carboxyl-terminal extension of the zinc finger region in the human vitamin D receptor
Hsieh J, Whitfield G, Oza A, Dang H, Price J, Galligan M, et al.
Biochemistry . 1999 Dec; 38(49):16347-58. PMID: 10587460
The vitamin D receptor (VDR) binds 1,25-dihydroxyvitamin D(3) and mediates its actions on gene transcription by heterodimerizing with retinoid X receptors (RXRs) on direct repeat (DR+3) vitamin D responsive elements...
6.
Vitamin D receptor displays DNA binding and transactivation as a heterodimer with the retinoid X receptor, but not with the thyroid hormone receptor
Thompson P, Hsieh J, Whitfield G, Haussler C, Jurutka P, Galligan M, et al.
J Cell Biochem . 1999 Oct; 75(3):462-80. PMID: 10536369
The vitamin D receptor (VDR) is a transcription factor believed to function as a heterodimer with the retinoid X receptor (RXR). However, it was reported [Schräder et al., 1994] that,...
7.
Vitamin D receptors from patients with resistance to 1,25-dihydroxyvitamin D3: point mutations confer reduced transactivation in response to ligand and impaired interaction with the retinoid X receptor heterodimeric partner
Whitfield G, Selznick S, Haussler C, Hsieh J, Galligan M, Jurutka P, et al.
Mol Endocrinol . 1996 Dec; 10(12):1617-31. PMID: 8961271
Hereditary hypocalcemic vitamin D-resistant rickets is attributable to defects in the nuclear receptor for 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. Two novel point mutations (I314S and R391C) identified in the hormone-binding domain of...
8.
Examination of the potential functional role of conserved cysteine residues in the hormone binding domain of the human 1,25-dihydroxyvitamin D3 receptor
Nakajima S, Hsieh J, Jurutka P, Galligan M, Haussler C, Whitfield G, et al.
J Biol Chem . 1996 Mar; 271(9):5143-9. PMID: 8617794
The significance of conserved cysteines at positions 288, 337, and 369 in the hormone binding domain of the human vitamin D receptor was evaluated by individual site-directed mutagenesis to glycine....
9.
1,25(OH)2D3-dependent regulation of calbindin-D28k mRNA requires ongoing protein synthesis in chick duodenal organ culture
Meyer J, Galligan M, Jones G, Komm B, Haussler C, Haussler M
J Cell Biochem . 1995 Jul; 58(3):315-27. PMID: 7593254
Organ culture of 19-day-old chick embryo duodena was utilized to evaluate the mechanism of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)-dependent calbindin-D28k (CaBP) expression. Duodenal CaBP and 1,25(OH)2D3 receptor (VDR) expression were assessed by...
10.
Receptor mediated genomic action of the 1,25(OH)2D3 hormone: expression of the human vitamin D receptor in E. coli
Hsieh J, Nakajima S, Galligan M, Jurutka P, Haussler C, Whitfield G, et al.
J Steroid Biochem Mol Biol . 1995 Jun; 53(1-6):583-94. PMID: 7626514
The nuclear vitamin D receptor (VDR) binds the 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) hormone with high affinity and elicits its actions to stimulate gene expression in target cells by binding to the...