Lynne Ling
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Explore the profile of Lynne Ling including associated specialties, affiliations and a list of published articles.
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10
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333
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Recent Articles
1.
Cai R, Ling L, Ghimire M, Brownell K, Caspary D
Hear Res
. 2024 Mar;
445:108993.
PMID: 38518392
Tinnitus is known to affect 10-15 % of the population, severely impacting 1-2 % of those afflicted. Canonically, tinnitus is generally a consequence of peripheral auditory damage resulting in maladaptive...
2.
Ghimire M, Cai R, Ling L, Brownell K, Wisner K, Cox B, et al.
Front Neurosci
. 2023 Jun;
17:1197909.
PMID: 37304018
Tinnitus impacts between 10-20% of the population. Individuals most troubled by their tinnitus have their attention bound to and are distracted by, their tinnitus percept. While numerous treatments to ameliorate...
3.
Ghimire M, Cai R, Ling L, Brownell K, Hackett T, Llano D, et al.
J Physiol
. 2023 Apr;
601(12):2493-2511.
PMID: 37119035
Tinnitus affects roughly 15%-20% of the population while severely impacting 10% of those afflicted. Tinnitus pathology is multifactorial, generally initiated by damage to the auditory periphery, resulting in a cascade...
4.
Kommajosyula S, Bartlett E, Cai R, Ling L, Caspary D
J Physiol
. 2021 Nov;
599(24):5465-5484.
PMID: 34783016
Ageing and challenging signal-in-noise conditions are known to engage the use of cortical resources to help maintain speech understanding. Extensive corticothalamic projections are thought to provide attentional, mnemonic and cognitive-related...
5.
Ghimire M, Cai R, Ling L, Hackett T, Caspary D
J Neurosci
. 2020 Jun;
40(30):5724-5739.
PMID: 32541068
The presence of novel or degraded communication sounds likely results in activation of basal forebrain cholinergic neurons increasing release of ACh onto presynaptic and postsynaptic nAChRs in primary auditory cortex...
6.
Sottile S, Hackett T, Cai R, Ling L, Llano D, Caspary D
J Neurosci
. 2017 Oct;
37(47):11377-11389.
PMID: 29061702
Acetylcholine (ACh) is a potent neuromodulator capable of modifying patterns of acoustic information flow. In auditory cortex, cholinergic systems have been shown to increase salience/gain while suppressing extraneous information. However,...
7.
Sottile S, Ling L, Cox B, Caspary D
J Physiol
. 2017 Jun;
595(15):5375-5385.
PMID: 28585699
Key Points: Neuronal nicotinic acetylcholine receptors (nAChRs) play a fundamental role in the attentional circuitry throughout the mammalian CNS. In the present study, we report a novel finding that ageing...
8.
Ling L, Caspary D
Bio Protoc
. 2016 Oct;
3(23).
PMID: 27747261
Gaboxadol (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol, THIP), a GABA receptor δ-subunit specific agonist, when present at low (μM) concentrations, preferentially binds and activates extrasynaptic (non-γ2, δ-subunit-containing) GABARs (Storustovu and Ebert, 2006; Richardson ., 2011,...
9.
Sametsky E, Turner J, Larsen D, Ling L, Caspary D
J Neurosci
. 2015 Jun;
35(25):9369-80.
PMID: 26109660
Accumulating evidence suggests a role for inhibitory neurotransmitter dysfunction in the pathology of tinnitus. Opposing hypotheses proposed either a pathologic decrease or increase of GABAergic inhibition in medial geniculate body...
10.
Caspary D, Ling L, Turner J, Hughes L
J Exp Biol
. 2008 May;
211(Pt 11):1781-91.
PMID: 18490394
Aging and acoustic trauma may result in partial peripheral deafferentation in the central auditory pathway of the mammalian brain. In accord with homeostatic plasticity, loss of sensory input results in...