Donald M Caspary
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Explore the profile of Donald M Caspary including associated specialties, affiliations and a list of published articles.
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38
Citations
1944
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Recent Articles
1.
Cai R, Ling L, Ghimire M, Brownell K, Caspary D
Hear Res
. 2024 Mar;
445:108993.
PMID: 38518392
Tinnitus is known to affect 10-15 % of the population, severely impacting 1-2 % of those afflicted. Canonically, tinnitus is generally a consequence of peripheral auditory damage resulting in maladaptive...
2.
Ghimire M, Cai R, Ling L, Brownell K, Wisner K, Cox B, et al.
Front Neurosci
. 2023 Jun;
17:1197909.
PMID: 37304018
Tinnitus impacts between 10-20% of the population. Individuals most troubled by their tinnitus have their attention bound to and are distracted by, their tinnitus percept. While numerous treatments to ameliorate...
3.
Ghimire M, Cai R, Ling L, Brownell K, Hackett T, Llano D, et al.
J Physiol
. 2023 Apr;
601(12):2493-2511.
PMID: 37119035
Tinnitus affects roughly 15%-20% of the population while severely impacting 10% of those afflicted. Tinnitus pathology is multifactorial, generally initiated by damage to the auditory periphery, resulting in a cascade...
4.
Kommajosyula S, Bartlett E, Cai R, Ling L, Caspary D
J Physiol
. 2021 Nov;
599(24):5465-5484.
PMID: 34783016
Ageing and challenging signal-in-noise conditions are known to engage the use of cortical resources to help maintain speech understanding. Extensive corticothalamic projections are thought to provide attentional, mnemonic and cognitive-related...
5.
Ghimire M, Cai R, Ling L, Hackett T, Caspary D
J Neurosci
. 2020 Jun;
40(30):5724-5739.
PMID: 32541068
The presence of novel or degraded communication sounds likely results in activation of basal forebrain cholinergic neurons increasing release of ACh onto presynaptic and postsynaptic nAChRs in primary auditory cortex...
6.
Kommajosyula S, Cai R, Bartlett E, Caspary D
J Physiol
. 2019 Mar;
597(10):2767-2784.
PMID: 30924931
Key Points: Temporal imprecision leads to deficits in the comprehension of signals in cluttered acoustic environments, and the elderly are shown to use cognitive resources to disambiguate these signals. To...
7.
Cai R, Montgomery S, Graves K, Caspary D, Cox B
Neurobiol Aging
. 2017 Nov;
62:53-63.
PMID: 29107847
Age-related hearing loss is experienced by one-third of individuals aged 65 years and older and can be socially debilitating. Historically, there has been poor correlation between age-related threshold changes, loss...
8.
Sottile S, Hackett T, Cai R, Ling L, Llano D, Caspary D
J Neurosci
. 2017 Oct;
37(47):11377-11389.
PMID: 29061702
Acetylcholine (ACh) is a potent neuromodulator capable of modifying patterns of acoustic information flow. In auditory cortex, cholinergic systems have been shown to increase salience/gain while suppressing extraneous information. However,...
9.
Sottile S, Ling L, Cox B, Caspary D
J Physiol
. 2017 Jun;
595(15):5375-5385.
PMID: 28585699
Key Points: Neuronal nicotinic acetylcholine receptors (nAChRs) play a fundamental role in the attentional circuitry throughout the mammalian CNS. In the present study, we report a novel finding that ageing...
10.
Cai R, Richardson B, Caspary D
J Neurosci
. 2016 Oct;
36(41):10696-10706.
PMID: 27733619
Significance Statement: Older individuals compensate for impaired ascending acoustic information by increasing use of cortical cognitive and attentional resources. The interplay between ascending and descending influences in the thalamus may...