Lynn Macdonald
Overview
Explore the profile of Lynn Macdonald including associated specialties, affiliations and a list of published articles.
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18
Citations
222
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Recent Articles
1.
Patel A, Trageser K, Kim H, Lim W, Adler C, Porter B, et al.
Blood Adv
. 2024 Sep;
8(23):5975-5987.
PMID: 39348688
A challenge for human immune system (HIS) mouse models has been the lack of human red blood cell (hRBC) survival after engraftment of these immune-deficient mice with human CD34+ hematopoietic...
2.
Wu J, Bloch N, Chang A, Bhavsar R, Wang Q, Crawford A, et al.
Cell Rep Med
. 2024 Sep;
5(10):101747.
PMID: 39326410
The clinical use of interleukin-2 (IL-2) for cancer immunotherapy is limited by severe toxicity. Emerging IL-2 therapies with reduced IL-2 receptor alpha (IL-2Rα) binding aim to mitigate toxicity and regulatory...
3.
Hunault L, Auria E, England P, Deschamps J, Briandet R, Kremer V, et al.
Gut Microbes
. 2024 Jan;
16(1):2301147.
PMID: 38289292
(), a gram-positive anaerobic and spore-forming bacterium, is the leading cause of nosocomial antibiotic-associated diarrhea in adults which is characterized by high levels of recurrence and mortality. Surface (S)-layer Protein...
4.
Hunault L, England P, Barbut F, Iannascoli B, Godon O, Dejardin F, et al.
Gut Pathog
. 2024 Jan;
16(1):4.
PMID: 38243246
Clostridioides difficile is the leading cause of antibiotic-associated diarrhea and pseudomembranous colitis in adults. Various C. difficile strains circulate currently, associated with different outcomes and antibiotic resistance profiles. However, most...
5.
Gao J, Ren S, Choonoo G, Chen G, Frleta D, Zhong J, et al.
Dis Model Mech
. 2023 Sep;
16(10).
PMID: 37718909
Sezary syndrome (SS) is a rare, aggressive leukemic variant of cutaneous T-cell lymphoma (CTCL) that lacks adequate therapeutic options and representative small-animal models. Here, we demonstrate that IL-15 is a...
6.
Lin W, Singh V, Springer R, Choonoo G, Gupta N, Patel A, et al.
Commun Biol
. 2023 May;
6(1):447.
PMID: 37185301
Efficacy of immune checkpoint inhibitors in cancers can be limited by CD8 T cell dysfunction or HLA-I down-regulation. Tumor control mechanisms independent of CD8/HLA-I axis would overcome these limitations. Here,...
7.
Patel A, Dhanik A, Lim W, Adler C, Ni M, Wei Y, et al.
Commun Biol
. 2023 Apr;
6(1):444.
PMID: 37087494
Immunodeficient mice reconstituted with a human immune system (HIS mice) give rise to human T cells, which make them an attractive system to study human immune responses to tumors. However,...
8.
Kwart D, He J, Srivatsan S, Lett C, Golubov J, Oswald E, et al.
Cell Rep
. 2022 Dec;
41(10):111769.
PMID: 36476866
Monocytes are highly plastic immune cells that modulate antitumor immunity. Therefore, identifying factors that regulate tumor monocyte functions is critical for developing effective immunotherapies. Here, we determine that endogenous cancer...
9.
Grosse-Michaelis I, Proestel S, Rao R, Dillman B, Bader-Weder S, Macdonald L, et al.
Ther Innov Regul Sci
. 2022 Aug;
57(1):1-6.
PMID: 35939205
The granularity and structure of the International Council for Harmonisation's (ICH) Medical Dictionary for Regulatory Activities (MedDRA) are useful for precise coding of adverse events (AEs) for data analysis. In...
10.
Devalaraja-Narashimha K, Meagher K, Luo Y, Huang C, Kaplan T, Muthuswamy A, et al.
J Am Soc Nephrol
. 2020 Dec;
32(1):99-114.
PMID: 33288630
Background: C3 glomerulopathy (C3G) is characterized by the alternative-pathway (AP) hyperactivation induced by nephritic factors or complement gene mutations. Mice deficient in complement factor H (CFH) are a classic C3G...