Lynn Geletka
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Explore the profile of Lynn Geletka including associated specialties, affiliations and a list of published articles.
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10
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879
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Recent Articles
1.
Porsche C, Delproposto J, Geletka L, ORourke R, Lumeng C
JCI Insight
. 2021 Mar;
6(8).
PMID: 33724954
Despite studies implicating adipose tissue T cells (ATT) in the initiation and persistence of adipose tissue inflammation, fundamental gaps in knowledge regarding ATT function impedes progress toward understanding how obesity...
2.
Russo L, Muir L, Geletka L, DelProposto J, Baker N, Flesher C, et al.
Mol Metab
. 2020 Apr;
39:100983.
PMID: 32229247
Objective: Expansion of visceral adipose tissue (VAT) and metabolic inflammation are consequences of obesity and associated with type 2 diabetes (T2DM). Metabolically activated adipose tissue macrophages (ATMs) undergo qualitative and...
3.
Muir L, Kiridena S, Griffin C, Delproposto J, Geletka L, Martinez-Santibanez G, et al.
J Leukoc Biol
. 2018 Mar;
103(4):615-628.
PMID: 29493813
Obesity-related changes in adipose tissue leukocytes, in particular adipose tissue macrophages (ATMs) and dendritic cells (ATDCs), are implicated in metabolic inflammation, insulin resistance, and altered regulation of adipocyte function. We...
4.
Cho K, Zamarron B, Muir L, Singer K, Porsche C, Delproposto J, et al.
J Immunol
. 2016 Sep;
197(9):3650-3661.
PMID: 27683748
Dynamic changes of adipose tissue leukocytes, including adipose tissue macrophage (ATM) and adipose tissue dendritic cells (ATDCs), contribute to obesity-induced inflammation and metabolic disease. However, clear discrimination between ATDC and...
5.
Muir L, Neeley C, Meyer K, Baker N, Brosius A, Washabaugh A, et al.
Obesity (Silver Spring)
. 2016 Feb;
24(3):597-605.
PMID: 26916240
Objective: The relationship between adipose tissue fibrosis, adipocyte hypertrophy, and preadipocyte hyperplasia in the context of obesity and the correlation of these tissue-based phenomena with systemic metabolic disease are poorly...
6.
Singer K, Maley N, Mergian T, DelProposto J, Cho K, Zamarron B, et al.
J Biol Chem
. 2015 Apr;
290(21):13250-62.
PMID: 25869128
Women of reproductive age are protected from metabolic disease relative to postmenopausal women and men. Most preclinical rodent studies are skewed toward the use of male mice to study obesity-induced...
7.
Cho K, Morris D, DelProposto J, Geletka L, Zamarron B, Martinez-Santibanez G, et al.
Cell Rep
. 2014 Oct;
9(2):605-17.
PMID: 25310975
An adaptive immune response triggered by obesity is characterized by the activation of adipose tissue CD4(+) T cells by unclear mechanisms. We have examined whether interactions between adipose tissue macrophages...
8.
Singer K, DelProposto J, Morris D, Zamarron B, Mergian T, Maley N, et al.
Mol Metab
. 2014 Aug;
3(6):664-75.
PMID: 25161889
Obesity is associated with an activated macrophage phenotype in multiple tissues that contributes to tissue inflammation and metabolic disease. To evaluate the mechanisms by which obesity potentiates myeloid activation, we...
9.
Inoue M, Jiang Y, Barnes 2nd R, Tokunaga M, Martinez-Santibanez G, Geletka L, et al.
Endocrinology
. 2013 Oct;
154(12):4548-59.
PMID: 24140711
Thrombospondin 1 (THBS1 or TSP-1) is a circulating glycoprotein highly expressed in hypertrophic visceral adipose tissues of humans and mice. High-fat diet (HFD) feeding induces the robust increase of circulating...
10.
Lumeng C, Liu J, Geletka L, Delaney C, DelProposto J, Desai A, et al.
J Immunol
. 2011 Nov;
187(12):6208-16.
PMID: 22075699
Age-related adiposity has been linked to chronic inflammatory diseases in late life. To date, the studies on adipose tissue leukocytes and aging have not taken into account the heterogeneity of...