Robert W ORourke
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Explore the profile of Robert W ORourke including associated specialties, affiliations and a list of published articles.
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70
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1742
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Recent Articles
1.
Wean J, Baranwal S, Miller N, Shin J, ORourke R, Burant C, et al.
Diabetes Metab
. 2024 Aug;
50(5):101570.
PMID: 39134173
Objective: Optimal weight loss involves decreasing adipose tissue while preserving lean muscle mass. Identifying molecular mediators that preserve lean muscle mass is therefore a clinically important goal. We have shown...
2.
Bozadjieva-Kramer N, Shin J, Li Z, Rupp A, Miller N, Kernodle S, et al.
JCI Insight
. 2024 Apr;
9(7).
PMID: 38587078
Fibroblast growth factor 15/19 (FGF15/19, mouse/human ortholog) is expressed in the ileal enterocytes of the small intestine and released postprandially in response to bile acid absorption. Previous reports of FGF15-/-...
3.
Ky A, McCoy A, Flesher C, Friend N, Li J, Akinleye K, et al.
Adipocyte
. 2023 Oct;
12(1):2268261.
PMID: 37815174
Alterations of the extracellular matrix contribute to adipose tissue dysfunction in metabolic disease. We studied the role of matrix density in regulating human adipocyte phenotype in a tunable hydrogel culture...
4.
Kang Q, Zhu X, Ren D, Ky A, MacDougald O, ORourke R, et al.
Adv Sci (Weinh)
. 2023 Aug;
10(28):e2301645.
PMID: 37526326
White adipose tissue (WAT) lipolysis releases free fatty acids as a key energy substance to support metabolism in fasting, cold exposure, and exercise. Atgl, in concert with Cgi-58, catalyzes the...
5.
Strieder-Barboza C, Flesher C, Geletka L, Eichler T, Akinleye O, Ky A, et al.
Adipocyte
. 2022 Dec;
11(1):665-675.
PMID: 36457256
Obesity-associated type 2 diabetes (DM) leads to adipose tissue dysfunction. Lumican is a proteoglycan implicated in obesity, insulin resistance (IR), and adipocyte dysfunction. Using human visceral adipose tissue (VAT) from...
6.
Muir L, Cho K, Geletka L, Baker N, Flesher C, Ehlers A, et al.
JCI Insight
. 2022 Jan;
7(3).
PMID: 34990410
Increased adipose tissue macrophages (ATMs) correlate with metabolic dysfunction in humans and are causal in development of insulin resistance in mice. Recent bulk and single-cell transcriptomics studies reveal a wide...
7.
Carruthers N, Strieder-Barboza C, Caruso J, Flesher C, Baker N, Kerk S, et al.
Sci Rep
. 2021 Aug;
11(1):17394.
PMID: 34462518
Dysfunctional visceral adipose tissue (VAT) in obesity is associated with type 2 diabetes (DM) but underlying mechanisms remain unclear. Our objective in this discovery analysis was to identify genes and...
8.
Azar S, Jamadar D, Wasnik A, ORourke R, Caoili E, Gandikota G
Clin Imaging
. 2021 Jan;
74:131-138.
PMID: 33493970
Objective: Spigelian hernia is an uncommon congenital or acquired defect in the transversus abdominis aponeurosis with non-specific symptoms posing a diagnostic challenge. There is a paucity of radiology literature on...
9.
ORourke R, Lumeng C
Obesity (Silver Spring)
. 2020 Dec;
29(4):645-653.
PMID: 33270351
Increased morbidity and mortality from coronavirus disease 2019 (COVID-19) in people with obesity have illuminated the intersection of obesity with impaired responses to infections. Although data on mechanisms by which...
10.
Wenderott J, Flesher C, Baker N, Neeley C, Varban O, Lumeng C, et al.
Sci Rep
. 2020 Nov;
10(1):20423.
PMID: 33235234
Obesity-related type 2 diabetes (DM) is a major public health concern. Adipose tissue metabolic dysfunction, including fibrosis, plays a central role in DM pathogenesis. Obesity is associated with changes in...