Lynette Ekunwe
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Explore the profile of Lynette Ekunwe including associated specialties, affiliations and a list of published articles.
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22
Citations
594
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Recent Articles
1.
Nicholas J, Raffield L, Katz D, Nicholas J, Tahir U, Katz D, et al.
Res Sq
. 2025 Feb;
PMID: 39989965
Measures from affinity-proteomics platforms often correlate poorly, challenging interpretation of protein associations with genetic variants (pQTL) and phenotypes. Here, we examined 2,157 proteins measured on both SomaScan 7k and Olink...
2.
Reiner A, Raffield L, Ekunwe L, Olson N, Auer P, Doyle M
Unknown
. 2024 Dec;
9(1).
PMID: 39720621
Sickle cell trait (SCT) has been associated with alterations in various immune-related laboratory parameters including lower circulating lymphocyte counts. To further characterize the impact of SCT on the immune system,...
3.
Tahir U, Barber J, Cruz D, Kars M, Deng S, Tuftin B, et al.
J Clin Invest
. 2024 Sep;
134(21).
PMID: 39316441
BACKGROUNDMost GWAS of plasma proteomics have focused on White individuals of European ancestry, limiting biological insight from other ancestry-enriched protein quantitative loci (pQTL).METHODSWe conducted a discovery GWAS of approximately 3,000...
4.
Huffman J, Nicholas J, Hahn J, Heath A, Raffield L, Yanek L, et al.
Blood
. 2024 Sep;
144(21):2248-2265.
PMID: 39226462
Genetic studies have identified numerous regions associated with plasma fibrinogen levels in Europeans, yet missing heritability and limited inclusion of non-Europeans necessitates further studies with improved power and sensitivity. Compared...
5.
Wen J, Sun Q, Huang L, Zhou L, Doyle M, Ekunwe L, et al.
Genetics
. 2024 Jul;
228(1).
PMID: 39056362
Most gene expression and alternative splicing quantitative trait loci (eQTL/sQTL) studies have been biased toward European ancestry individuals. Here, we performed eQTL and sQTL analyses using TOPMed whole-genome sequencing-derived genotype...
6.
Rao P, Keyes M, Mi M, Barber J, Tahir U, Deng S, et al.
JAMA Cardiol
. 2024 Jun;
9(8):713-722.
PMID: 38865108
Importance: Blood pressure response during acute exercise (exercise blood pressure [EBP]) is associated with the future risk of hypertension and cardiovascular disease (CVD). Biochemical characterization of EBP could inform disease...
7.
de Vries P, Reventun P, Brown M, Heath A, Huffman J, Le N, et al.
Blood
. 2024 Feb;
143(18):1845-1855.
PMID: 38320121
Coagulation factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are critical to coagulation and platelet aggregation. We leveraged whole-genome sequence data from the Trans-Omics for Precision Medicine...
8.
Huffman J, Nicolas J, Hahn J, Heath A, Raffield L, Yanek L, et al.
medRxiv
. 2023 Jul;
PMID: 37398003
Key Points: Largest and most diverse genetic study of plasma fibrinogen identifies 54 regions (18 novel), housing 69 conditionally distinct variants (20 novel).Sufficient power achieved to identify signal driven by...
9.
Wen J, Sun Q, Huang L, Zhou L, Doyle M, Ekunwe L, et al.
bioRxiv
. 2023 May;
PMID: 37163084
Most gene expression and alternative splicing quantitative trait loci (eQTL/sQTL) studies have been biased toward European ancestry individuals. Here, we performed eQTL and sQTL analysis using TOPMed whole genome sequencing-derived...
10.
Mikhaylova A, McHugh C, Polfus L, Raffield L, Boorgula M, Blackwell T, et al.
Am J Hum Genet
. 2021 Sep;
108(10):1836-1851.
PMID: 34582791
Many common and rare variants associated with hematologic traits have been discovered through imputation on large-scale reference panels. However, the majority of genome-wide association studies (GWASs) have been conducted in...