Lynda F Bonewald
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Explore the profile of Lynda F Bonewald including associated specialties, affiliations and a list of published articles.
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131
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10460
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Recent Articles
1.
Welc S, Brotto M, White K, Bonewald L
Mech Ageing Dev
. 2025 Feb;
224:112039.
PMID: 39952614
Musculoskeletal health is strongly influenced by regulatory interactions of bone and muscle. Recent discoveries have identified a number of key mechanisms through which soluble factors released during exercise by bone...
2.
Sakamoto E, Kitase Y, Fitt A, Zhu Z, Awad K, Brotto M, et al.
Cell Rep
. 2024 Jun;
43(7):114397.
PMID: 38935499
With exercise, muscle and bone produce factors with beneficial effects on brain, fat, and other organs. Exercise in mice increased fibroblast growth factor 23 (FGF23), urine phosphate, and the muscle...
3.
Shimonty A, Pin F, Prideaux M, Peng G, Huot J, Kim H, et al.
Elife
. 2024 Apr;
12.
PMID: 38661340
Irisin, released from exercised muscle, has been shown to have beneficial effects on numerous tissues but its effects on bone are unclear. We found significant sex and genotype differences in...
4.
Shimonty A, Pin F, Prideaux M, Peng G, Huot J, Kim H, et al.
bioRxiv
. 2023 Nov;
PMID: 37986762
Irisin, released from exercised muscle, has been shown to have beneficial effects on numerous tissues but its effects on bone are unclear. We found significant sex and genotype differences in...
5.
Prideaux M, Smargiassi A, Peng G, Brotto M, Robling A, Bonewald L
JBMR Plus
. 2023 Jun;
7(6):e10746.
PMID: 37283651
The L-enantiomer of β-aminoisobutyric acid (BAIBA) is secreted by contracted muscle in mice, and exercise increases serum levels in humans. In mice, L-BAIBA reduces bone loss with unloading, but whether...
6.
Shimonty A, Bonewald L, Huot J
Calcif Tissue Int
. 2023 May;
113(1):21-38.
PMID: 37193929
Maintenance of skeletal health is tightly regulated by osteocytes, osteoblasts, and osteoclasts via coordinated secretion of bone-derived factors, termed osteokines. Disruption of this coordinated process due to aging and metabolic...
7.
Shimonty A, Bonewald L, Pin F
Curr Osteoporos Rep
. 2023 Apr;
21(3):303-310.
PMID: 37084017
Purpose Of The Review: The purpose of this review is to summarize the role of the osteocyte in muscle atrophy in cancer patients, sarcopenia, spinal cord injury, Duchenne's muscular dystrophy,...
8.
Williams J, Irwin M, Li Y, Kambrath A, Mattingly B, Patel S, et al.
Int J Mol Sci
. 2023 Mar;
24(5).
PMID: 36902150
Calcium/calmodulin (CaM)-dependent protein kinase kinase 2 (CaMKK2) regulates bone remodeling through its effects on osteoblasts and osteoclasts. However, its role in osteocytes, the most abundant bone cell type and the...
9.
Agoro R, Nookaew I, Noonan M, Marambio Y, Liu S, Chang W, et al.
Front Endocrinol (Lausanne)
. 2023 Feb;
14:1063083.
PMID: 36777346
Introduction: Due to a lack of spatial-temporal resolution at the single cell level, the etiologies of the bone dysfunction caused by diseases such as normal aging, osteoporosis, and the metabolic...
10.
Yoshimoto T, Kittaka M, Doan A, Urata R, Prideaux M, Rojas R, et al.
Nat Commun
. 2022 Nov;
13(1):6648.
PMID: 36333322
The impact of bone cell activation on bacterially-induced osteolysis remains elusive. Here, we show that matrix-embedded osteocytes stimulated with bacterial pathogen-associated molecular patterns (PAMPs) directly drive bone resorption through an...