Lyn Smurthwaite
Overview
Explore the profile of Lyn Smurthwaite including associated specialties, affiliations and a list of published articles.
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5
Citations
403
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Recent Articles
1.
Takhar P, Corrigan C, Smurthwaite L, OConnor B, Durham S, Lee T, et al.
J Allergy Clin Immunol
. 2007 Jan;
119(1):213-8.
PMID: 17208604
Background: Class switching from IgM/IgG/IgA to IgE is required for B cells to express IgE. This requires class switch recombination in the Ig heavy-chain gene locus. It is generally believed...
2.
Takhar P, Smurthwaite L, Coker H, Fear D, Banfield G, Carr V, et al.
J Immunol
. 2005 Apr;
174(8):5024-32.
PMID: 15814733
IgE-expressing B cells are over 1000 times more frequent in the nasal B cell than the peripheral blood B cell population. We have investigated the provenance of these B cells...
3.
Gould H, Sutton B, Beavil A, Beavil R, McCloskey N, Coker H, et al.
Annu Rev Immunol
. 2002 Dec;
21:579-628.
PMID: 12500981
Allergic individuals exposed to minute quantities of allergen experience an immediate response. Immediate hypersensitivity reflects the permanent sensitization of mucosal mast cells by allergen-specific IgE antibodies bound to their high-affinity...
4.
Smurthwaite L, Durham S
Curr Allergy Asthma Rep
. 2002 Mar;
2(3):231-8.
PMID: 11918865
Local IgE production has been a contentious concept for over 40 years. Although a host of clinical observations suggested a local source of IgE, co-localization of IgE to B cells...
5.
Wilson D, Merrett T, Varga E, Smurthwaite L, Gould H, Kemp M, et al.
Am J Respir Crit Care Med
. 2002 Jan;
165(1):22-6.
PMID: 11779725
IgE is important in both early and late allergic responses. Increases in the numbers of RNA transcripts coding for IgE have been observed in the bronchial mucosa of asthmatics and...