Lyn M Wancket
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Explore the profile of Lyn M Wancket including associated specialties, affiliations and a list of published articles.
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16
Citations
212
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Recent Articles
1.
OBrien M, Schuh J, Wancket L, Cramer S, Funk K, Jackson N, et al.
Toxicol Pathol
. 2022 Jun;
50(4):512-530.
PMID: 35762822
Nonclinical implantation studies are a common and often critical step for medical device safety assessment in the bench-to-market pathway. Nonclinical implanted medical devices or drug-device combination products require complex macroscopic...
2.
Wancket L
Toxicol Pathol
. 2018 Nov;
47(3):339-343.
PMID: 30411668
Lymph nodes and associated lymphatics filter extracellular fluid and lymph to maintain tissue-fluid balance and detect distant tissue injury. Examination of regional draining lymph nodes (RDLs; lymph nodes that drain...
3.
Elmore S, Carreira V, Labriola C, Mahapatra D, McKeag S, Rinke M, et al.
Toxicol Pathol
. 2018 Oct;
46(8):865-897.
PMID: 30282530
The 2018 annual National Toxicology Program Satellite Symposium, entitled "Pathology Potpourri," was held in Indianapolis, Indiana, at the Society of Toxicologic Pathology's 37th annual meeting. The goal of this symposium...
4.
Elmore S, Aeffner F, Bangari D, Crabbs T, Fossey S, Gad S, et al.
Toxicol Pathol
. 2017 Nov;
45(7):799-833.
PMID: 29113559
The 2017 annual National Toxicology Program Satellite Symposium, entitled "Pathology Potpourri," was held in Montreal, Quebec, Canada at the Society of Toxicologic Pathology's 36th annual meeting. The goal of this...
5.
Wancket L
Toxicol Pathol
. 2017 Nov;
45(7):925-930.
PMID: 29105579
Repair of bone and joint tissue to restore normal function is a unique endeavor that requires recreating tissue structure and the integrated healing of both organic and inorganic tissue components....
6.
Crowell S, Wancket L, Shakibi Y, Xu P, Xue J, Samavati L, et al.
J Biol Chem
. 2014 Sep;
289(42):28753-64.
PMID: 25204653
MAPK phosphatases (MKPs) are critical modulators of the innate immune response, and yet the mechanisms regulating their accumulation remain poorly understood. In the present studies, we investigated the role of...
7.
Wancket L, Meng X, Rogers L, Liu Y
Toxicol Pathol
. 2012 May;
40(8):1095-105.
PMID: 22623522
c-Jun N-terminal kinase (JNK) activation promotes hepatocyte death during acetaminophen overdose, a common cause of drug-induced liver failure. While mitogen-activated protein kinase (MAPK) phosphatase (Mkp)-1 is a critical negative regulator...
8.
Matta R, Barnard J, Wancket L, Yan J, Xue J, Grieves J, et al.
Am J Physiol Gastrointest Liver Physiol
. 2012 Mar;
302(11):G1322-35.
PMID: 22461024
Il-10-deficient mice develop colitis associated with exaggerated Th1/Th17 responses and are a valuable model of inflammatory bowel disease. Mkp-1 is a major negative regulator of MAPKs, and its expression is...
9.
Yan J, Meng X, Wancket L, Lintner K, Nelin L, Chen B, et al.
J Immunol
. 2012 Jan;
188(5):2316-27.
PMID: 22279102
Glutathione reductase (Gsr) catalyzes the reduction of glutathione disulfide to glutathione, which plays an important role in the bactericidal function of phagocytes. Because Gsr has been implicated in the oxidative...
10.
Wancket L, Frazier W, Liu Y
Life Sci
. 2011 Dec;
90(7-8):237-48.
PMID: 22197448
Mitogen-activated protein kinases (MAPKs) are key regulators of cellular physiology and immune responses, and abnormalities in MAPKs are implicated in many diseases. MAPKs are activated by MAPK kinases through phosphorylation...