Lutz Nuhn
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Explore the profile of Lutz Nuhn including associated specialties, affiliations and a list of published articles.
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Articles
72
Citations
831
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Recent Articles
1.
Maksymova L, Pilger Y, Nuhn L, Van Ginderachter J
Mol Cancer
. 2025 Mar;
24(1):65.
PMID: 40033293
Among the emerging strategies for cancer theranostics, nanomedicines offer significant promise in advancing both patients' diagnosis and treatment. In combination with nanobodies, nanomedicines can potentially enhance the precision and efficiency...
2.
Bixenmann L, Nuhn L
Macromol Rapid Commun
. 2025 Feb;
:e2500082.
PMID: 39950719
Hemiacetal esters are versatile functional groups known for their unique ability to degrade under mild conditions such as exposure to water, alcohols, organic acids, or heat. In this study, hemiacetal...
3.
Komforth P, Imschweiler J, Hesse M, Heck A, Fuchs A, Hauck A, et al.
Biomacromolecules
. 2024 Dec;
26(1):387-404.
PMID: 39632270
Postpolymerization modifications are valuable techniques for creating functional polymers that are challenging to synthesize directly. This study presents aliphatic polycarbonates with pendant thiol-reactive groups for disulfide formation with mercaptans. The...
4.
Fuchs A, Czysch C, Maxeiner K, Winterwerber P, Schmitt S, Stickdorn J, et al.
Small
. 2024 Dec;
:e2406082.
PMID: 39618014
Cationic, core-crosslinked nanogel particles are prepared from synthetic biodegradable materials. These fully hydrophilic nanogels offer superior customizability compared to common lipid nanoparticles, thereby circumventing intrinsic immune stimulatory properties. Electrostatic loading...
5.
Hauck A, Komforth P, Erlenbusch J, Stickdorn J, Radacki K, Braunschweig H, et al.
Biomater Sci
. 2024 Nov;
13(6):1414-1425.
PMID: 39575699
Pharmacokinetics and biodistribution profiles of active substances are crucial aspects for their safe and successful administration. Since many immunogenic compounds do not meet all requirements for safe and effective administration,...
6.
Bixenmann L, Ahmad T, Stephan F, Nuhn L
Biomacromolecules
. 2024 Nov;
25(12):7958-7974.
PMID: 39509250
Polymers with hemiacetal esters integrated in their backbone provide beneficial degradation profiles for (immuno-) drug delivery. However, their fast hydrolysis and low drug loading capacity have limited their applications so...
7.
Zhong Z, Deventer M, Chen Y, Vanhee S, Lammens I, Deswarte K, et al.
Angew Chem Int Ed Engl
. 2024 Oct;
64(7):e202419031.
PMID: 39441822
Opioid use disorder - particularly involving fentanyl - has precipitated a public health crisis characterized by a significant increase in addiction and overdose-related deaths. Fentanyl-specific immunotherapy, which aims at inducing...
8.
Heck A, Medina-Montano C, Zhong Z, Deswarte K, Eigen K, Stickdorn J, et al.
Adv Healthc Mater
. 2024 Sep;
13(32):e2402875.
PMID: 39313985
Gaining spatial control over innate immune activation is of great relevance during vaccine delivery and anticancer therapy, where one aims at activating immune cells at draining lymphoid tissue while avoiding...
9.
Heck A, Stickdorn J, Rosenberger L, Scherger M, Woller J, Eigen K, et al.
J Am Chem Soc
. 2023 Dec;
145(50):27424-27436.
PMID: 38054646
The design of functional polymers coupled with stimuli-triggered drug release mechanisms is a promising achievement to overcome various biological barriers. pH trigger methods yield significant potential for controlled targeting and...
10.
Stickdorn J, Czysch C, Medina-Montano C, Stein L, Xu L, Scherger M, et al.
Int J Mol Sci
. 2023 Oct;
24(20).
PMID: 37895096
For successful therapeutic interventions in cancer immunotherapy, strong antigen-specific immune responses are required. To this end, immunostimulating cues must be combined with antigens to simultaneously arrive at antigen-presenting cells and...