Lulzim Shkreta
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Explore the profile of Lulzim Shkreta including associated specialties, affiliations and a list of published articles.
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30
Citations
1129
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Recent Articles
1.
Zahedi Amiri A, Ahmed C, Dahal S, Grosso F, Leng H, Stoilov P, et al.
Viruses
. 2025 Jan;
17(1).
PMID: 39861843
Treatment options for viral infections are limited and viruses have proven adept at evolving resistance to many existing therapies, highlighting a significant vulnerability in our defenses. In response to this...
2.
Shkreta L, Delannoy A, Toutant J, Chabot B
RNA
. 2024 Sep;
30(12):1596-1607.
PMID: 39251328
The CLK1 kinase phosphorylates SR proteins to modulate their splicing regulatory activity. Skipping of alternative exon 4 on the pre-mRNA produces a CLK1 variant lacking the catalytic site. Here, we...
3.
Shkreta L, Toutant J, Delannoy A, Durantel D, Salvetti A, Ehresmann S, et al.
Oncotarget
. 2024 May;
15:313-325.
PMID: 38753413
The diheteroarylamide-based compound 1C8 and the aminothiazole carboxamide-related compound GPS167 inhibit the CLK kinases, and affect the proliferation of a broad range of cancer cell lines. A chemogenomic screen previously...
4.
Dahal S, Clayton K, Been T, Fernet-Brochu R, Villasmil Ocando A, Balachandran A, et al.
Retrovirology
. 2022 Aug;
19(1):18.
PMID: 35986377
Background: The generation of over 69 spliced HIV-1 mRNAs from one primary transcript by alternative RNA splicing emphasizes the central role that RNA processing plays in HIV-1 replication. Control is...
5.
Dahal S, Cheng R, Cheung P, Been T, Malty R, Geng M, et al.
Viruses
. 2022 Jan;
14(1).
PMID: 35062264
Medicinal chemistry optimization of a previously described stilbene inhibitor of HIV-1, 5350150 (2-(2-(5-nitro-2-thienyl)vinyl)quinoline), led to the identification of the thiazole-5-carboxamide derivative (GPS491), which retained potent anti-HIV-1 activity with reduced toxicity....
6.
Sohail M, Shkreta L, Toutant J, Rabea S, Babeu J, Huard C, et al.
NAR Cancer
. 2021 Jul;
3(2):zcab019.
PMID: 34316707
The elevated expression of the splicing regulator SRSF10 in metastatic colorectal cancer (CRC) stimulates the production of the pro-tumorigenic splice variant. We discovered a group of small molecules with an...
7.
Shkreta L, Delannoy A, Salvetti A, Chabot B
RNA
. 2021 Jul;
27(11):1302-1317.
PMID: 34315816
Serine/arginine splicing factor 10 (SRSF10) is a member of the family of mammalian splicing regulators known as SR proteins. Like several of its SR siblings, the SRSF10 protein is composed...
8.
Pastor F, Shkreta L, Chabot B, Durantel D, Salvetti A
Front Microbiol
. 2021 Apr;
12:658721.
PMID: 33854493
Protein phosphorylation constitutes a major post-translational modification that critically regulates the half-life, intra-cellular distribution, and activity of proteins. Among the large number of kinases that compose the human kinome tree,...
9.
Tetreault M, Deshaies J, Semmler S, Sidibe H, Shkreta L, Volkening K, et al.
Brain
. 2018 Oct;
141(12):e84.
PMID: 30364932
No abstract available.
10.
Deshaies J, Shkreta L, Moszczynski A, Sidibe H, Semmler S, Fouillen A, et al.
Brain
. 2018 Mar;
141(5):1320-1333.
PMID: 29562314
See Fratta and Isaacs (doi:10.1093/brain/awy091) for a scientific commentary on this article.The RNA binding proteins TDP-43 (encoded by TARDBP) and hnRNP A1 (HNRNPA1) are each mutated in certain amyotrophic lateral...