Sherif Abou Elela
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Explore the profile of Sherif Abou Elela including associated specialties, affiliations and a list of published articles.
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71
Citations
2402
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Recent Articles
1.
Faucher-Giguere L, de Preval B, Rivera A, Scott M, Elela S
Philos Trans R Soc Lond B Biol Sci
. 2025 Mar;
380(1921):20230376.
PMID: 40045787
Ribosomes are heterogeneous in terms of their constituent proteins, structural RNAs and ribosomal RNA (rRNA) modifications, resulting in diverse potential translatomes. rRNA modifications, guided by small nucleolar RNAs (snoRNAs), enable...
2.
Petibon C, Catala M, Morales D, Panchapakesan S, Unrau P, Elela S
Nucleic Acids Res
. 2025 Jan;
53(2).
PMID: 39817510
In baker's yeast, genes encoding ribosomal proteins often exist as duplicate pairs, typically with one 'major' paralog highly expressed and a 'minor' less expressed paralog that undergoes controlled expression through...
3.
Lecuyer E, Sauvageau M, Kothe U, Unrau P, Damha M, Perreault J, et al.
Biochem Cell Biol
. 2024 Sep;
102(6):472-491.
PMID: 39320985
The field of RNA research has provided profound insights into the basic mechanisms modulating the function and adaption of biological systems. RNA has also been at the center stage in...
4.
Bergeron D, Faucher-Giguere L, Emmerichs A, Choquet K, Song K, Deschamps-Francoeur G, et al.
Genome Biol
. 2023 Jul;
24(1):160.
PMID: 37415181
Background: Small nucleolar RNAs (snoRNAs) are abundant noncoding RNAs best known for their involvement in ribosomal RNA maturation. In mammals, most expressed snoRNAs are embedded in introns of longer genes...
5.
Kerkhofs K, Garg J, Fafard-Couture E, Elela S, Scott M, Pearlman R, et al.
Nat Commun
. 2022 Nov;
13(1):7332.
PMID: 36443289
Nascent pre-tRNAs are transcribed by RNA polymerase III and immediately bound by La proteins on the UUU-3'OH sequence, using a tandem arrangement of the La motif and an adjacent RNA...
6.
Bergeron D, Paraqindes H, Fafard-Couture E, Deschamps-Francoeur G, Faucher-Giguere L, Bouchard-Bourelle P, et al.
Nucleic Acids Res
. 2022 Sep;
51(D1):D291-D296.
PMID: 36165892
snoDB is an interactive database of human small nucleolar RNAs (snoRNAs) that includes up-to-date information on snoRNA features, genomic location, conservation, host gene, snoRNA-RNA targets and snoRNA abundance and provides...
7.
Malik Ghulam M, Catala M, Reulet G, Scott M, Elela S
Nat Commun
. 2022 Aug;
13(1):4938.
PMID: 35999447
Ribosomes are often seen as monolithic machines produced from uniformly regulated genes. However, in yeast most ribosomal proteins come from duplicated genes. Here, we demonstrate that gene duplication may serve...
8.
Zhou D, Tran Y, Elela S, Scott M
BMC Bioinformatics
. 2022 Jun;
23(1):250.
PMID: 35751026
Background: Alternative splicing can increase the diversity of gene functions by generating multiple isoforms with different sequences and functions. However, the extent to which splicing events have functional consequences remains...
9.
Faucher-Giguere L, Roy A, Deschamps-Francoeur G, Couture S, Nottingham R, Lambowitz A, et al.
NAR Cancer
. 2022 Jan;
4(1):zcab050.
PMID: 35047824
Small nucleolar RNAs (snoRNAs) are an omnipresent class of non-coding RNAs involved in the modification and processing of ribosomal RNA (rRNA). As snoRNAs are required for ribosome production, the increase...
10.
Zhou D, Couture S, Scott M, Elela S
Nucleic Acids Res
. 2021 Jul;
49(14):8370-8383.
PMID: 34244793
RBFOX2 controls the splicing of a large number of transcripts implicated in cell differentiation and development. Parsing RNA-binding protein datasets, we uncover that RBFOX2 can interact with hnRNPC, hnRNPM and...