Luke McCaffrey
Overview
Explore the profile of Luke McCaffrey including associated specialties, affiliations and a list of published articles.
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28
Citations
405
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Recent Articles
1.
Meunier A, Hernandez-Castro J, Chahley N, Communal L, Kheireddine S, Koushki N, et al.
Commun Med (Lond)
. 2025 Feb;
5(1):33.
PMID: 39900650
Background: Circulating tumor cells (CTCs) are rare (a few cells per milliliter of blood) and mostly isolated as single-cell CTCs (scCTCs). CTC clusters (cCTCs), even rarer, are of growing interest,...
2.
Guo Q, Li V, Nichol J, Huang F, Yang W, Preston S, et al.
Cancer Res
. 2024 Apr;
84(8):1373.
PMID: 38616659
No abstract available.
3.
Viala S, Hadjadj C, Nathan V, Guiot M, McCaffrey L, Cockburn K, et al.
Mol Biol Cell
. 2023 Nov;
35(2):br5.
PMID: 37991903
Loss of cell polarity and disruption of tissue organization are key features of tumorigenesis that are intrinsically linked to spindle orientation. Epithelial tumors are often characterized by spindle orientation defects,...
4.
Liu L, Xiao B, Hirukawa A, Smith H, Zuo D, Sanguin-Gendreau V, et al.
Proc Natl Acad Sci U S A
. 2023 Aug;
120(33):e2303010120.
PMID: 37549258
The regulation of gene expression through histone posttranslational modifications plays a crucial role in breast cancer progression. However, the molecular mechanisms underlying the contribution of histone modification to tumor initiation...
5.
Whitford M, McCaffrey L
Curr Top Dev Biol
. 2023 Apr;
154:245-283.
PMID: 37100520
Mammary gland development and breast cancer progression are associated with extensive remodeling of epithelial tissue architecture. Apical-basal polarity is a key feature of epithelial cells that coordinates key elements of...
6.
Lee W, Boghdady C, Lelarge V, Leask R, McCaffrey L, Moraes C
Biomaterials
. 2023 Mar;
296:122073.
PMID: 36905756
Measuring internal mechanical stresses within 3D tissues can provide important insights into drivers of morphogenesis and disease progression. Cell-sized hydrogel microspheres have recently emerged as a powerful technique to probe...
7.
Lebeau B, Jangal M, Zhao T, Wong C, Wong N, Cepeda Canedo E, et al.
Proc Natl Acad Sci U S A
. 2022 Aug;
119(36):e2203452119.
PMID: 36037342
The contribution of deregulated chromatin architecture, including topologically associated domains (TADs), to cancer progression remains ambiguous. CCCTC-binding factor (CTCF) is a central regulator of higher-order chromatin structure that undergoes copy...
8.
Catterall R, Kurdieh R, McCaffrey L
Methods Mol Biol
. 2022 Feb;
2438:455-466.
PMID: 35147957
Epithelial tissues are highly organized structures that are structured at both the cellular and tissue levels. Individual cells are characterized by an apical membrane facing a central lumen, and a...
9.
Wang L, Proulx M, Kim A, Lelarge V, McCaffrey L
Sci Rep
. 2021 Nov;
11(1):22807.
PMID: 34815476
Apical-basal cell polarity and lumen formation are essential features of many epithelial tissues, which are disrupted in diseases like cancer. Here, we describe a proteomics-based screen to identify proteins involved...
10.
Belharbi S, Rony J, Dolz J, Ben Ayed I, McCaffrey L, Granger E
IEEE Trans Med Imaging
. 2021 Oct;
41(3):702-714.
PMID: 34705638
Weakly-supervised learning (WSL) has recently triggered substantial interest as it mitigates the lack of pixel-wise annotations. Given global image labels, WSL methods yield pixel-level predictions (segmentations), which enable to interpret...