Luke McAlary
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Explore the profile of Luke McAlary including associated specialties, affiliations and a list of published articles.
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33
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583
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Recent Articles
1.
Ediriweera G, Sivaram A, Cowin G, Brown M, McAlary L, Lum J, et al.
J Control Release
. 2024 Dec;
378:221-235.
PMID: 39645085
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with extremely limited therapeutic options. One key pathological feature of ALS is the abnormal accumulation of misfolded proteins within motor neurons....
2.
Lambert-Smith I, Shephard V, McAlary L, Yerbury J, Saunders D
Sci Rep
. 2024 Jun;
14(1):13844.
PMID: 38879591
Disrupted proteome homeostasis (proteostasis) in amyotrophic lateral sclerosis (ALS) has been a major focus of research in the past two decades. However, the proteostasis processes that become disturbed in ALS...
3.
McAlary L, Nan J, Shyu C, Sher M, Plotkin S, Cashman N
Open Biol
. 2024 Jun;
14(6):230418.
PMID: 38835240
Mutations in the protein superoxide dismutase-1 (SOD1) promote its misfolding and aggregation, ultimately causing familial forms of the debilitating neurodegenerative disease amyotrophic lateral sclerosis (ALS). Currently, over 220 (mostly missense)...
4.
Shephard V, Brown M, Thompson B, Harpur A, McAlary L
Amyotroph Lateral Scler Frontotemporal Degener
. 2024 May;
25(5-6):608-614.
PMID: 38742757
Variants of the oxygen free radical scavenging enzyme superoxide dismutase-1 (SOD1) are associated with the neurodegenerative disease amyotrophic lateral sclerosis (ALS). These variants occur in roughly 20% of familial ALS...
5.
Pokrishevsky E, DuVal M, McAlary L, Louadi S, Pozzi S, Roman A, et al.
J Biol Chem
. 2024 Mar;
300(5):107207.
PMID: 38522514
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of motor neurons. Neuronal superoxide dismutase-1 (SOD1) inclusion bodies are characteristic of familial ALS with SOD1 mutations, while a hallmark of...
6.
Scherer N, Maurel C, Graus M, McAlary L, Richter G, Radford R, et al.
Nucleic Acids Res
. 2024 Feb;
52(9):5301-5319.
PMID: 38381071
Insoluble cytoplasmic aggregate formation of the RNA-binding protein TDP-43 is a major hallmark of neurodegenerative diseases including Amyotrophic Lateral Sclerosis. TDP-43 localizes predominantly in the nucleus, arranging itself into dynamic...
7.
Hossain M, Sarin R, Donnelly D, Miller B, Weiss A, McAlary L, et al.
PLoS Biol
. 2024 Jan;
22(1):e3002462.
PMID: 38289969
Mutations in the gene encoding Cu-Zn superoxide dismutase 1 (SOD1) cause a subset of familial amyotrophic lateral sclerosis (fALS) cases. A shared effect of these mutations is that SOD1, which...
8.
Genenger B, McAlary L, Perry J, Ashford B, Ranson M
STAR Protoc
. 2023 Jun;
4(2):102331.
PMID: 37300829
Multi-cellular tumor spheroids (MCTS) have found widespread use in pre-clinical research. However, their complex three-dimensional structure makes immunofluorescent staining and imaging challenging. Here, we present a protocol for whole spheroid...
9.
Farrawell N, Bax M, McAlary L, McKenna J, Maksour S, Do-Ha D, et al.
Hum Mol Genet
. 2023 May;
32(14):2386-2398.
PMID: 37220877
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal neurodegenerative disorders that share pathological features, including the aberrant accumulation of ubiquitinated protein inclusions within motor neurons. Previously, we have...
10.
McAlary L, Shephard V, Sher M, Rice L, Yerbury J, Cashman N, et al.
STAR Protoc
. 2022 Oct;
3(4):101748.
PMID: 36201320
Proteinaceous inclusions are associated with neurodegenerative diseases and cell models are often used to determine genetic and chemical modifiers of their formation. This protocol involves the usage of automated microscopy...