Luke Jostins
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Explore the profile of Luke Jostins including associated specialties, affiliations and a list of published articles.
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Recent Articles
21.
Jostins L, McVean G
Bioinformatics
. 2016 Feb;
32(12):1898-900.
PMID: 26873930
Motivation: For many classes of disease the same genetic risk variants underly many related phenotypes or disease subtypes. Multinomial logistic regression provides an attractive framework to analyze multi-category phenotypes, and...
22.
Cleynen I, Boucher G, Jostins L, Schumm L, Zeissig S, Ahmad T, et al.
Lancet
. 2015 Oct;
387(10014):156-67.
PMID: 26490195
Background: Crohn's disease and ulcerative colitis are the two major forms of inflammatory bowel disease; treatment strategies have historically been determined by this binary categorisation. Genetic studies have identified 163...
23.
Moutsianas L, Jostins L, Beecham A, Dilthey A, Xifara D, Ban M, et al.
Nat Genet
. 2015 Sep;
47(10):1107-1113.
PMID: 26343388
Association studies have greatly refined the understanding of how variation within the human leukocyte antigen (HLA) genes influences risk of multiple sclerosis. However, the extent to which major effects are...
24.
Liu J, van Sommeren S, Huang H, Ng S, Alberts R, Takahashi A, et al.
Nat Genet
. 2015 Jul;
47(9):979-986.
PMID: 26192919
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease (IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or Immunochip genotype...
25.
Goyette P, Boucher G, Mallon D, Ellinghaus E, Jostins L, Huang H, et al.
Nat Genet
. 2015 Jan;
47(2):172-9.
PMID: 25559196
Genome-wide association studies of the related chronic inflammatory bowel diseases (IBD) known as Crohn's disease and ulcerative colitis have shown strong evidence of association to the major histocompatibility complex (MHC)....
26.
Fairfax B, Humburg P, Makino S, Naranbhai V, Wong D, Lau E, et al.
Science
. 2014 Mar;
343(6175):1246949.
PMID: 24604202
To systematically investigate the impact of immune stimulation upon regulatory variant activity, we exposed primary monocytes from 432 healthy Europeans to interferon-γ (IFN-γ) or differing durations of lipopolysaccharide and mapped...
27.
Jostins L, Levine A, Barrett J
PLoS One
. 2013 Nov;
8(10):e76328.
PMID: 24204614
A central focus of complex disease genetics after genome-wide association studies (GWAS) is to identify low frequency and rare risk variants, which may account for an important fraction of disease...
28.
Band G, Le Q, Jostins L, Pirinen M, Kivinen K, Jallow M, et al.
PLoS Genet
. 2013 May;
9(5):e1003509.
PMID: 23717212
Combining data from genome-wide association studies (GWAS) conducted at different locations, using genotype imputation and fixed-effects meta-analysis, has been a powerful approach for dissecting complex disease genetics in populations of...
29.
Hunt K, Mistry V, Bockett N, Ahmad T, Ban M, Barker J, et al.
Nature
. 2013 May;
498(7453):232-5.
PMID: 23698362
Genome-wide association studies (GWAS) have identified common variants of modest-effect size at hundreds of loci for common autoimmune diseases; however, a substantial fraction of heritability remains unexplained, to which rare...
30.
Jostins L, Ripke S, Weersma R, Duerr R, McGovern D, Hui K, et al.
Nature
. 2012 Nov;
491(7422):119-24.
PMID: 23128233
Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease (IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other populations. Genome-wide association...