Luke Jostins
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Explore the profile of Luke Jostins including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Rivas M, Avila B, Koskela J, Huang H, Stevens C, Pirinen M, et al.
PLoS Genet
. 2018 May;
14(5):e1007329.
PMID: 29795570
As part of a broader collaborative network of exome sequencing studies, we developed a jointly called data set of 5,685 Ashkenazi Jewish exomes. We make publicly available a resource of...
12.
Cortes A, Dendrou C, Motyer A, Jostins L, Vukcevic D, Dilthey A, et al.
Nat Genet
. 2017 Aug;
49(9):1311-1318.
PMID: 28759005
Genetic discovery from the multitude of phenotypes extractable from routine healthcare data can transform understanding of the human phenome and accelerate progress toward precision medicine. However, a critical question when...
13.
Huang H, Fang M, Jostins L, Mirkov M, Boucher G, Anderson C, et al.
Nature
. 2017 Jun;
547(7662):173-178.
PMID: 28658209
Inflammatory bowel diseases are chronic gastrointestinal inflammatory disorders that affect millions of people worldwide. Genome-wide association studies have identified 200 inflammatory bowel disease-associated loci, but few have been conclusively resolved...
14.
Lee J, Biasci D, Roberts R, Gearry R, Mansfield J, Ahmad T, et al.
Nat Genet
. 2017 Jan;
49(2):262-268.
PMID: 28067912
For most immune-mediated diseases, the main determinant of patient well-being is not the diagnosis itself but instead the course that the disease takes over time (prognosis). Prognosis may vary substantially...
15.
Luo Y, de Lange K, Jostins L, Moutsianas L, Randall J, Kennedy N, et al.
Nat Genet
. 2017 Jan;
49(2):186-192.
PMID: 28067910
To further resolve the genetic architecture of the inflammatory bowel diseases ulcerative colitis and Crohn's disease, we sequenced the whole genomes of 4,280 patients at low coverage and compared them...
16.
de Lange K, Moutsianas L, Lee J, Lamb C, Luo Y, Kennedy N, et al.
Nat Genet
. 2017 Jan;
49(2):256-261.
PMID: 28067908
Genetic association studies have identified 215 risk loci for inflammatory bowel disease, thereby uncovering fundamental aspects of its molecular biology. We performed a genome-wide association study of 25,305 individuals and...
17.
Ji S, Juran B, Mucha S, Folseraas T, Jostins L, Melum E, et al.
Nat Genet
. 2016 Dec;
49(2):269-273.
PMID: 27992413
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction; ∼75% of patients have comorbid inflammatory bowel disease (IBD). We undertook the largest genome-wide association study...
18.
Dendrou C, Cortes A, Shipman L, Evans H, Attfield K, Jostins L, et al.
Sci Transl Med
. 2016 Nov;
8(363):363ra149.
PMID: 27807284
Thousands of genetic variants have been identified, which contribute to the development of complex diseases, but determining how to elucidate their biological consequences for translation into clinical benefit is challenging....
19.
Levine A, Pontikos N, Schiff E, Jostins L, Speed D, Lovat L, et al.
Gastroenterology
. 2016 Jul;
151(4):698-709.
PMID: 27373512
Background & Aims: Crohn's disease (CD) is a highly heritable disease that is particularly common in the Ashkenazi Jewish population. We studied 2 large Ashkenazi Jewish families with a high...
20.
Ellinghaus D, Jostins L, Spain S, Cortes A, Bethune J, Han B, et al.
Nat Genet
. 2016 Mar;
48(5):510-8.
PMID: 26974007
We simultaneously investigated the genetic landscape of ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis and ulcerative colitis to investigate pleiotropy and the relationship between these clinically related diseases. Using...