Luke Isbel
Overview
Explore the profile of Luke Isbel including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
437
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0
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Recent Articles
1.
Michael A, Stoos L, Crosby P, Eggers N, Nie X, Makasheva K, et al.
Nature
. 2023 Jul;
619(7969):385-393.
PMID: 37407816
The basic helix-loop-helix (bHLH) family of transcription factors recognizes DNA motifs known as E-boxes (CANNTG) and includes 108 members. Here we investigate how chromatinized E-boxes are engaged by two structurally...
2.
Isbel L, Iskar M, Durdu S, Weiss J, Grand R, Hietter-Pfeiffer E, et al.
Nat Struct Mol Biol
. 2023 Jun;
30(7):948-957.
PMID: 37386214
The genomic binding sites of the transcription factor (TF) and tumor suppressor p53 are unusually diverse with regard to their chromatin features, including histone modifications, raising the possibility that the...
3.
Yelagandula R, Stecher K, Novatchkova M, Michetti L, Michlits G, Wang J, et al.
Nat Cell Biol
. 2023 Jan;
25(1):42-55.
PMID: 36604593
ZNF462 haploinsufficiency is linked to Weiss-Kruszka syndrome, a genetic disorder characterized by neurodevelopmental defects, including autism. Though conserved in vertebrates and essential for embryonic development, the molecular functions of ZNF462...
4.
Isbel L, Grand R, Schubeler D
Nat Rev Genet
. 2022 Jul;
23(12):728-740.
PMID: 35831531
Cell type-specific gene expression relies on transcription factors (TFs) binding DNA sequence motifs embedded in chromatin. Understanding how motifs are accessed in chromatin is crucial to comprehend differential transcriptional responses...
5.
Grand R, Burger L, Grawe C, Michael A, Isbel L, Hess D, et al.
Nature
. 2021 Jul;
596(7870):133-137.
PMID: 34234345
The majority of gene transcripts generated by RNA polymerase II in mammalian genomes initiate at CpG island (CGI) promoters, yet our understanding of their regulation remains limited. This is in...
6.
Michael A, Grand R, Isbel L, Cavadini S, Kozicka Z, Kempf G, et al.
Science
. 2020 Apr;
368(6498):1460-1465.
PMID: 32327602
Transcription factors (TFs) regulate gene expression through chromatin where nucleosomes restrict DNA access. To study how TFs bind nucleosome-occupied motifs, we focused on the reprogramming factors OCT4 and SOX2 in...
7.
Hartl D, Krebs A, Grand R, Baubec T, Isbel L, Wirbelauer C, et al.
Genome Res
. 2019 Feb;
29(4):554-563.
PMID: 30709850
Most mammalian RNA polymerase II initiation events occur at CpG islands, which are rich in CpGs and devoid of DNA methylation. Despite their relevance for gene regulation, it is unknown...
8.
Isbel L, Schubeler D
Cell
. 2018 Nov;
175(5):1179-1181.
PMID: 30445037
In this issue, Kazachenka, Bertozzi, and colleagues identify elements in the mouse genome with epigenetic variability between littermates, a phenomenon linked to transmission of phenotypes over generations. This addresses two...
9.
Russo A, Lawther A, Prior B, Isbel L, Somers W, Lesku J, et al.
Behav Brain Res
. 2018 Jun;
359:918-926.
PMID: 29935278
Autism spectrum disorder (ASD) is a heterogeneous and highly heritable condition with multiple aetiologies. Although the biological mechanisms underlying ASD are not fully understood, evidence suggests that dysregulation of serotonergic...
10.
Isbel L, Prokopuk L, Wu H, Daxinger L, Oey H, Spurling A, et al.
Elife
. 2016 Jul;
5.
PMID: 27410475
We previously identified Wiz in a mouse screen for epigenetic modifiers. Due to its known association with G9a/GLP, Wiz is generally considered a transcriptional repressor. Here, we provide evidence that...