Lucia Daxinger
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Explore the profile of Lucia Daxinger including associated specialties, affiliations and a list of published articles.
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48
Citations
2321
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Recent Articles
1.
Vukic M, Chouaref J, Della Chiara V, Dogan S, Ratner F, Hogenboom J, et al.
Sci Adv
. 2024 Feb;
10(6):eadk3384.
PMID: 38335290
Disruption of cell division cycle associated 7 (CDCA7) has been linked to aberrant DNA hypomethylation, but the impact of DNA methylation loss on transcription has not been investigated. Here, we...
2.
Tapia Del Fierro A, den Hamer B, Benetti N, Jansz N, Chen K, Beck T, et al.
Nat Commun
. 2023 Sep;
14(1):5466.
PMID: 37749075
The interplay between 3D chromatin architecture and gene silencing is incompletely understood. Here, we report a novel point mutation in the non-canonical SMC protein SMCHD1 that enhances its silencing capacity...
3.
Liu Y, Sinke L, Jonkman T, Slieker R, van Zwet E, Daxinger L, et al.
Clin Epigenetics
. 2023 Aug;
15(1):135.
PMID: 37626340
Background: Loss of epigenetic control is a hallmark of aging. Among the most prominent roles of epigenetic mechanisms is the inactivation of one of two copies of the X chromosome...
4.
Sikrova D, Testa A, Willemsen I, van den Heuvel A, Tapscott S, Daxinger L, et al.
Commun Biol
. 2023 Jun;
6(1):677.
PMID: 37380887
Facioscapulohumeral muscular dystrophy (FSHD) is caused by the epigenetic derepression of the 4q-linked D4Z4 macrosatellite repeat resulting in inappropriate expression of the D4Z4 repeat-encoded DUX4 gene in skeletal muscle. In...
5.
Wang Z, Coban B, Wu H, Chouaref J, Daxinger L, Paulsen M, et al.
Cell Commun Signal
. 2023 Jan;
21(1):15.
PMID: 36691073
Grainyhead like 2 (GRHL2) is an essential transcription factor for development and function of epithelial tissues. It has dual roles in cancer by supporting tumor growth while suppressing epithelial to...
6.
Pagliaroli L, Porazzi P, Curtis A, Scopa C, Mikkers H, Freund C, et al.
Nat Commun
. 2021 Nov;
12(1):6469.
PMID: 34753942
Subunit switches in the BAF chromatin remodeler are essential during development. ARID1B and its paralog ARID1A encode for mutually exclusive BAF subunits. De novo ARID1B haploinsufficient mutations cause neurodevelopmental disorders,...
7.
Desai V, Chouaref J, Wu H, Pastor W, Kan R, Oey H, et al.
Epigenetics Chromatin
. 2021 Oct;
14(1):49.
PMID: 34706774
Background: Microrchidia proteins (MORCs) are involved in epigenetic gene silencing in a variety of eukaryotic organisms. Deletion of MORCs result in several developmental abnormalities and their dysregulation has been implicated...
8.
Dongen J, Gordon S, McRae A, Odintsova V, Mbarek H, Breeze C, et al.
Nat Commun
. 2021 Sep;
12(1):5618.
PMID: 34584077
Monozygotic (MZ) twins and higher-order multiples arise when a zygote splits during pre-implantation stages of development. The mechanisms underpinning this event have remained a mystery. Because MZ twinning rarely runs...
9.
Della Chiara V, Daxinger L, Staal F
Cells
. 2021 May;
10(5).
PMID: 33946533
Hematopoietic multipotent progenitors seed the thymus and then follow consecutive developmental stages until the formation of mature T cells. During this process, phenotypic changes of T cells entail stage-specific transcriptional...
10.
van den Heuvel D, Spruijt C, Gonzalez-Prieto R, Kragten A, Paulsen M, Zhou D, et al.
Nat Commun
. 2021 Feb;
12(1):1342.
PMID: 33637760
Bulky DNA lesions in transcribed strands block RNA polymerase II (RNAPII) elongation and induce a genome-wide transcriptional arrest. The transcription-coupled repair (TCR) pathway efficiently removes transcription-blocking DNA lesions, but how...