Luke Frankiw
Overview
Explore the profile of Luke Frankiw including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
266
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0
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Recent Articles
1.
Wang Y, Wang Z, Yang J, Lei X, Liu Y, Frankiw L, et al.
Adv Sci (Weinh)
. 2024 Feb;
11(13):e2305750.
PMID: 38342599
Deciphering cellular interactions is essential to both understand the mechanisms underlying a broad range of human diseases, but also to manipulate therapies targeting these diseases. Here, the formation of cell...
2.
Frankiw L, Singh A, Peters C, Comin-Anduix B, Berent-Maoz B, Macabali M, et al.
J Immunother Cancer
. 2023 May;
11(5).
PMID: 37156551
Background: The tumor antigen NY-ESO-1 has been shown to be an effective target for transgenic adoptive cell therapy (ACT) for the treatment of sarcoma and melanoma. However, despite frequent early...
3.
Cheng H, Qiu Y, Xu Y, Chen L, Ma K, Tao M, et al.
Nat Metab
. 2023 Jan;
5(2):314-330.
PMID: 36717749
The accumulation of acidic metabolic waste products within the tumor microenvironment inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it remains unclear how an acidic environment affects T cell metabolism...
4.
5.
Su Y, Ko M, Cheng H, Zhu R, Xue M, Wang J, et al.
Nat Commun
. 2020 May;
11(1):2345.
PMID: 32393797
The determination of individual cell trajectories through a high-dimensional cell-state space is an outstanding challenge for understanding biological changes ranging from cellular differentiation to epigenetic responses of diseased cells upon...
6.
Frankiw L, Mann M, Li G, Joglekar A, Baltimore D
RNA
. 2019 Nov;
26(2):126-136.
PMID: 31740586
At the heart of an innate immune response lies a tightly regulated gene expression program. This precise regulation is crucial because small changes can shift the balance from protective to...
7.
Frankiw L, Baltimore D, Li G
Nat Rev Immunol
. 2019 Aug;
19(11):675-687.
PMID: 31363190
Immunotherapies are yielding effective treatments for several previously untreatable cancers. Still, the identification of suitable antigens specific to the tumour that can be targets for cancer vaccines and T cell...
8.
Frankiw L, Majumdar D, Burns C, Vlach L, Moradian A, Sweredoski M, et al.
Mol Cell
. 2019 Jan;
73(4):803-814.e6.
PMID: 30639243
Intron retention (IR) has emerged as an important mechanism of gene expression control, but the factors controlling IR events remain poorly understood. We observed consistent IR in one intron of...