David Baltimore
Overview
Explore the profile of David Baltimore including associated specialties, affiliations and a list of published articles.
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Articles
168
Citations
22074
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Recent Articles
1.
Albright T, Baltimore D, Mazza A, Mnookin J, Tatel D
Proc Natl Acad Sci U S A
. 2023 Oct;
120(41):e2312529120.
PMID: 37782804
For nearly 25 y, the Committee on Science, Technology, and Law (CSTL), of the National Academies of Sciences, Engineering, and Medicine, has brought together distinguished members of the science and...
2.
3.
Foy S, Jacoby K, Bota D, Hunter T, Pan Z, Stawiski E, et al.
Nature
. 2022 Nov;
615(7953):687-696.
PMID: 36356599
T cell receptors (TCRs) enable T cells to specifically recognize mutations in cancer cells. Here we developed a clinical-grade approach based on CRISPR-Cas9 non-viral precision genome-editing to simultaneously knockout the...
4.
Casazza J, Cale E, Narpala S, Yamshchikov G, Coates E, Hendel C, et al.
Nat Med
. 2022 Apr;
28(5):1022-1030.
PMID: 35411076
Adeno-associated viral vector-mediated transfer of DNA coding for broadly neutralizing anti-HIV antibodies (bnAbs) offers an alternative to attempting to induce protection by vaccination or by repeated infusions of bnAbs. In...
5.
Hirokawa S, Chure G, Belliveau N, Lovely G, Anaya M, Schatz D, et al.
Nucleic Acids Res
. 2020 May;
48(12):6726-6739.
PMID: 32449932
Developing lymphocytes of jawed vertebrates cleave and combine distinct gene segments to assemble antigen-receptor genes. This process called V(D)J recombination that involves the RAG recombinase binding and cutting recombination signal...
6.
Su Y, Ko M, Cheng H, Zhu R, Xue M, Wang J, et al.
Nat Commun
. 2020 May;
11(1):2345.
PMID: 32393797
The determination of individual cell trajectories through a high-dimensional cell-state space is an outstanding challenge for understanding biological changes ranging from cellular differentiation to epigenetic responses of diseased cells upon...
7.
Su Y, Wang X, Mann M, Adamus T, Wang D, Moreira D, et al.
Blood
. 2019 Dec;
135(3):167-180.
PMID: 31805184
NF-κB is a key regulator of inflammation and cancer progression, with an important role in leukemogenesis. Despite its therapeutic potential, targeting NF-κB using pharmacologic inhibitors has proven challenging. Here, we...
8.
Frankiw L, Mann M, Li G, Joglekar A, Baltimore D
RNA
. 2019 Nov;
26(2):126-136.
PMID: 31740586
At the heart of an innate immune response lies a tightly regulated gene expression program. This precise regulation is crucial because small changes can shift the balance from protective to...
9.
Ng A, Peng S, Xu A, Noh W, Guo K, Bethune M, et al.
Lab Chip
. 2019 Sep;
19(18):3011-3021.
PMID: 31502632
Adaptive immunity is based on peptide antigen recognition. Our ability to harness the immune system for therapeutic gain relies on the discovery of the T cell receptor (TCR) genes that...
10.
Peng S, Zaretsky J, Ng A, Chour W, Bethune M, Choi J, et al.
Cell Rep
. 2019 Sep;
28(10):2728-2738.e7.
PMID: 31484081
Neoantigen-specific T cells are increasingly viewed as important immunotherapy effectors, but physically isolating these rare cell populations is challenging. Here, we describe a sensitive method for the enumeration and isolation...