Lukas J A C Hawinkels
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Explore the profile of Lukas J A C Hawinkels including associated specialties, affiliations and a list of published articles.
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65
Citations
2267
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Recent Articles
21.
Harryvan T, de Lange S, Hawinkels L, Verdegaal E
Int J Mol Sci
. 2022 Jan;
23(1).
PMID: 35008560
Professional antigen-presenting cells (APCs), such as dendritic cells and macrophages, are known for their ability to present exogenous antigens to T cells. However, many other cell types, including endothelial cells,...
22.
Schoonderwoerd M, Hakuno S, Sassen M, Kuhlemaijer E, Paauwe M, Slingerland M, et al.
Onco Targets Ther
. 2021 Nov;
14:5205-5220.
PMID: 34744438
Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms of cancer and is known to have low immunogenicity and an immunosuppressive microenvironment. It is also characterized by...
23.
Ouahoud S, Jacobs R, Kodach L, Voorneveld P, Hawinkels L, Weil N, et al.
Br J Cancer
. 2021 Oct;
126(2):297-301.
PMID: 34703008
Background: Long-term use of statins is associated with a small reduced risk of colorectal cancer but their mechanism of action is not well understood. While they are generally believed to...
24.
Epithelial argininosuccinate synthetase is dispensable for intestinal regeneration and tumorigenesis
van der Meer J, de Boer R, Meijer B, Smit W, Vermeulen J, Meisner S, et al.
Cell Death Dis
. 2021 Oct;
12(10):897.
PMID: 34599156
The epithelial signaling pathways involved in damage and regeneration, and neoplastic transformation are known to be similar. We noted upregulation of argininosuccinate synthetase (ASS1) in hyperproliferative intestinal epithelium. Since ASS1...
25.
Ouahoud S, Jacobs R, Peppelenbosch M, Fuhler G, Heijmans J, Diks S, et al.
Br J Cancer
. 2021 May;
125(1):144.
PMID: 33972748
No abstract available.
26.
Sier V, van der Vorst J, Quax P, de Vries M, Zonoobi E, Vahrmeijer A, et al.
Int J Mol Sci
. 2021 May;
22(9).
PMID: 33946583
Molecular imaging of pathologic lesions can improve efficient detection of cancer and cardiovascular diseases. A shared pathophysiological feature is angiogenesis, the formation of new blood vessels. Endoglin (CD105) is a...
27.
Heinrich M, M R H Mostafa A, Morton J, Hawinkels L, Prakash J
Adv Drug Deliv Rev
. 2021 Apr;
174:265-293.
PMID: 33895214
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive type of cancer with an overall survival rate of less than 7-8%, emphasizing the need for novel effective therapeutics against PDAC. However...
28.
Ouahoud S, Jacobs R, Peppelenbosch M, Fuhler G, Heijmans J, Diks S, et al.
Br J Cancer
. 2021 Mar;
124(12):1978-1987.
PMID: 33742146
Background: Epidemiological studies and meta-analyses show an association between statin use and a reduced incidence of colorectal cancer (CRC). We have shown that statins act on CRC through bone morphogenetic...
29.
Dang H, van Pelt G, Haasnoot K, Backes Y, Elias S, Seerden T, et al.
United European Gastroenterol J
. 2021 Feb;
PMID: 33566452
Background: Current risk stratification models for early invasive (T1) colorectal cancer are not able to discriminate accurately between prognostic favourable and unfavourable tumours, resulting in over-treatment of a large (>80%)...
30.
Dang H, Harryvan T, Hawinkels L
Cancers (Basel)
. 2021 Jan;
13(2).
PMID: 33430285
In intestinal homeostasis, continuous renewal of the epithelium is crucial to withstand the plethora of stimuli which can damage the structural integrity of the intestines. Fibroblasts contribute to this renewal...