Lukas C Heukamp
Overview
Explore the profile of Lukas C Heukamp including associated specialties, affiliations and a list of published articles.
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Articles
105
Citations
4633
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Recent Articles
21.
Michels S, Heydt C, van Veggel B, Deschler-Baier B, Pardo N, Monkhorst K, et al.
JCO Precis Oncol
. 2020 Sep;
3.
PMID: 32914023
Purpose: Third-generation epidermal growth factor receptor () tyrosine kinase inhibitors (TKIs) are effective in acquired resistance (AR) to early-generation EGFR TKIs in EGFR-mutant lung cancer. However, efficacy is marked by...
22.
Schatz S, Falk M, Jori B, Ramdani H, Schmidt S, Willing E, et al.
Cancers (Basel)
. 2020 Jul;
12(6).
PMID: 32599951
In recent years, Non-small cell lung cancer (NSCLC) has evolved into a prime example for precision oncology with multiple FDA-approved "precision" drugs. For the majority of NSCLC lacking targetable genetic...
23.
Volz C, Breid S, Selenz C, Zaplatina A, Golfmann K, Meder L, et al.
Cell Rep
. 2020 Apr;
31(4):107568.
PMID: 32348765
Anti-angiogenic treatment targeting vascular endothelial growth factor (VEGF)-VEGFR2 signaling has shown limited efficacy in lung cancer patients. Here, we demonstrate that inhibition of VEGFR2 in tumor cells, expressed in ∼20%...
24.
Schulte R, Wohlleber D, Unrau L, Geers B, Metzger C, Erhardt A, et al.
Int J Mol Sci
. 2020 Apr;
21(7).
PMID: 32260486
The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) regulates target gene expression upon ligand binding. Apart from its effects on metabolism, PPARγ activity can inhibit the production of pro-inflammatory cytokines...
25.
Roeper J, Falk M, Chalaris-Rissmann A, Lueers A, Ramdani H, Wedeken K, et al.
Oncotarget
. 2020 Feb;
11(3):250-264.
PMID: 32076486
Introduction: The impact of TP53 co-mutations in EGFR mutated patients on PFS and OS is controversial. Different classifications of TP53 mutations with respect to functional and potential clinical impact have...
26.
Bochtler T, Reiling A, Endris V, Hielscher T, Volckmar A, Neumann O, et al.
Int J Cancer
. 2020 Jan;
146(11):3053-3064.
PMID: 31970771
Cancer of unknown primary (CUP) denotes a malignancy with histologically confirmed metastatic spread while the primary tumor remains elusive. Here, we address prognostic and therapeutic implications of mutations and copy...
27.
Endig J, Unrau L, Sprezyna P, Rading S, Karsak M, Goltz D, et al.
Int J Mol Sci
. 2019 Nov;
20(22).
PMID: 31698731
Myeloid cells are essential for the initiation and termination of innate and adaptive immunity that create homeostasis in the liver. Smad7 is an inhibitor of the transforming growth factor β...
28.
Tolksdorf F, Mikulec J, Geers B, Endig J, Sprezyna P, Heukamp L, et al.
Sci Rep
. 2018 Nov;
8(1):16123.
PMID: 30382149
Interleukin-2 (IL-2) is a key regulator of adaptive immune responses but its regulation is incompletely understood. We previously found that PDL1-dependent signals were pivotal for liver sinusoidal endothelial cell-mediated priming...
29.
Frank R, Scheffler M, Merkelbach-Bruse S, Ihle M, Kron A, Rauer M, et al.
Clin Cancer Res
. 2018 Apr;
24(13):3087-3096.
PMID: 29615460
and mutations are associated with impaired prognosis in a variety of cancers and with squamous cell carcinoma formation in non-small cell lung cancer (NSCLC). However, little is known about frequency,...
30.
Meder L, Konig K, Dietlein F, Macheleidt I, Florin A, Ercanoglu M, et al.
Oncogene
. 2018 Mar;
37(20):2746-2756.
PMID: 29503447
LIN28B is a RNA-binding protein regulating predominantly let-7 microRNAs with essential functions in inflammation, wound healing, embryonic stem cells, and cancer. LIN28B expression is associated with tumor initiation, progression, resistance,...