Luis R Cruz-Vera
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Explore the profile of Luis R Cruz-Vera including associated specialties, affiliations and a list of published articles.
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13
Citations
157
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Recent Articles
1.
Functional domains of a ribosome arresting peptide are affected by surrounding nonconserved residues
Judd H, Martinez A, Klepacki D, Vazquez-Laslop N, Sachs M, Cruz-Vera L
J Biol Chem
. 2024 Feb;
300(3):105780.
PMID: 38395310
Expression of the Escherichia coli tnaCAB operon, responsible for L-tryptophan (L-Trp) transport and catabolism, is regulated by L-Trp-directed translation arrest and the ribosome arresting peptide TnaC. The function of TnaC...
2.
Worthan S, Franklin E, Pham C, Yap M, Cruz-Vera L
Microbiol Spectr
. 2022 Mar;
10(2):e0226121.
PMID: 35311583
Mutational changes in bacterial ribosomes often affect gene expression and consequently cellular fitness. Understanding how mutant ribosomes disrupt global gene expression is critical to determining key genetic factors that affect...
3.
van der Stel A, Gordon E, Sengupta A, Martinez A, Klepacki D, Perry T, et al.
Nat Commun
. 2021 Sep;
12(1):5340.
PMID: 34504068
Free L-tryptophan (L-Trp) stalls ribosomes engaged in the synthesis of TnaC, a leader peptide controlling the expression of the Escherichia coli tryptophanase operon. Despite extensive characterization, the molecular mechanism underlying...
4.
Martinez A, Gordon E, Sengupta A, Shirole N, Klepacki D, Martinez-Garriga B, et al.
Nucleic Acids Res
. 2013 Oct;
42(2):1245-56.
PMID: 24137004
A transcriptional attenuation mechanism regulates expression of the bacterial tnaCAB operon. This mechanism requires ribosomal arrest induced by the regulatory nascent TnaC peptide in response to free L-tryptophan (L-Trp). In...
5.
McFeeters H, Gilbert M, Thompson R, Setzer W, Cruz-Vera L, McFeeters R
Nat Prod Commun
. 2012 Sep;
7(8):1107-10.
PMID: 22978241
Peptidyl-tRNA Hydrolase (Pth) is a highly conserved, essential enzyme in bacteria. It removes the peptide portion from peptidyl-tRNA, returning free tRNAs to participate in translation. Build-up of peptidyl-tRNAs is toxic...
6.
Harris S, McFeeters H, Ogungbe I, Cruz-Vera L, Setzer W, Jackes B, et al.
Nat Prod Commun
. 2011 Dec;
6(10):1421-4.
PMID: 22164773
With the rapid rise of antibiotic resistance in pathogenic bacteria, the need for new antibacterial agents is overwhelming. Herein we report the limited screening of tropical plant extracts for inhibitory...
7.
Martinez A, Shirole N, Murakami S, Benedik M, Sachs M, Cruz-Vera L
Nucleic Acids Res
. 2011 Nov;
40(5):2247-57.
PMID: 22110039
Translation of the TnaC nascent peptide inhibits ribosomal activity in the presence of l-tryptophan, inducing expression of the tnaCAB operon in Escherichia coli. Using chemical methylation, this work reveals how...
8.
Cruz-Vera L, Yang R, Yanofsky C
J Bacteriol
. 2009 Sep;
191(22):7001-6.
PMID: 19767424
Expression of the tna operon of Escherichia coli and of Proteus vulgaris is induced by L-tryptophan. In E. coli, tryptophan action is dependent on the presence of several critical residues...
9.
Yang R, Cruz-Vera L, Yanofsky C
J Bacteriol
. 2009 Mar;
191(11):3445-50.
PMID: 19329641
Distinct features of the ribosomal peptide exit tunnel are known to be essential for recognition of specific amino acids of a nascent peptidyl-tRNA. Thus, a tryptophan residue at position 12...
10.
Cruz-Vera L, Yanofsky C
J Bacteriol
. 2008 Apr;
190(14):4791-7.
PMID: 18424524
In Escherichia coli, interactions between the nascent TnaC-tRNA(Pro) peptidyl-tRNA and the translating ribosome create a tryptophan binding site in the ribosome where bound tryptophan inhibits TnaC-tRNA(Pro) cleavage. This inhibition delays...