Luis Fonseca-Ornelas
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Explore the profile of Luis Fonseca-Ornelas including associated specialties, affiliations and a list of published articles.
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15
Citations
484
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Recent Articles
1.
Ramalingam N, Jin S, Moors T, Fonseca-Ornelas L, Shimanaka K, Lei S, et al.
NPJ Parkinsons Dis
. 2023 Jan;
9(1):4.
PMID: 36646701
In Parkinson's disease and other synucleinopathies, the elevation of α-synuclein phosphorylated at Serine129 (pS129) is a widely cited marker of pathology. However, the physiological role for pS129 has remained undefined....
2.
Fonseca-Ornelas L, Stricker J, Soriano-Cruz S, Weykopf B, Dettmer U, Muratore C, et al.
NPJ Parkinsons Dis
. 2022 Sep;
8(1):118.
PMID: 36114228
α-Synuclein (αSyn) aggregation in Lewy bodies and neurites defines both familial and 'sporadic' Parkinson's disease. We previously identified α-helically folded αSyn tetramers, in addition to the long-known unfolded monomers, in...
3.
Fonseca-Ornelas L, Viennet T, Rovere M, Jiang H, Liu L, Nuber S, et al.
Cell Rep
. 2021 Jul;
36(1):109333.
PMID: 34233191
While misfolding of alpha-synuclein (αSyn) is central to the pathogenesis of Parkinson's disease (PD), fundamental questions about its structure and function at the synapse remain unanswered. We examine synaptosomes from...
4.
Rovere M, Powers A, Jiang H, Pitino J, Fonseca-Ornelas L, Patel D, et al.
J Biol Chem
. 2019 May;
294(25):9799-9812.
PMID: 31048377
Parkinson's disease (PD) is one of the most common neurodegenerative disorders, and both genetic and histopathological evidence have implicated the ubiquitous presynaptic protein α-synuclein (αSyn) in its pathogenesis. Recent work...
5.
Pinho R, Paiva I, Jercic K, Fonseca-Ornelas L, Gerhardt E, Fahlbusch C, et al.
Hum Mol Genet
. 2018 Sep;
28(1):31-50.
PMID: 30219847
Alpha-synuclein (aSyn) is a central player in Parkinson's disease (PD) but the precise molecular mechanisms underlying its pathogenicity remain unclear. It has recently been suggested that nuclear aSyn may modulate...
6.
Rovere M, Sanderson J, Fonseca-Ornelas L, Patel D, Bartels T
FEBS Lett
. 2018 Apr;
592(9):1464-1472.
PMID: 29633780
α-Synuclein (αSyn) is a key player in the pathogenesis of Parkinson's disease and other synucleinopathies. Here, we report the existence of a novel soluble α-helical conformer of αSyn, obtained through...
7.
Fonseca-Ornelas L, Schmidt C, Camacho-Zarco A, Fernandez C, Becker S, Zweckstetter M
Chemistry
. 2017 Aug;
23(53):13010-13014.
PMID: 28763125
Accumulation of α-synuclein (αSyn) aggregates constitutes the hallmark of synucleinopathies including Parkinson's disease. However, many steps from the innocuous, monomeric αSyn toward misfolded oligomers and fibrillar species remain unclear. Here,...
8.
de Oliveira R, Miranda H, Francelle L, Pinho R, Szego E, Martinho R, et al.
PLoS Biol
. 2017 Apr;
15(4):e1002601.
PMID: 28379951
[This corrects the article DOI: 10.1371/journal.pbio.2000374.].
9.
de Oliveira R, Miranda H, Francelle L, Pinho R, Szego E, Martinho R, et al.
PLoS Biol
. 2017 Mar;
15(3):e2000374.
PMID: 28257421
Sirtuin genes have been associated with aging and are known to affect multiple cellular pathways. Sirtuin 2 was previously shown to modulate proteotoxicity associated with age-associated neurodegenerative disorders such as...
10.
Villar-Pique A, da Fonseca T, SantAnna R, Szego E, Fonseca-Ornelas L, Pinho R, et al.
Proc Natl Acad Sci U S A
. 2016 Oct;
113(42):E6506-E6515.
PMID: 27708160
Synucleinopathies are a group of progressive disorders characterized by the abnormal aggregation and accumulation of α-synuclein (aSyn), an abundant neuronal protein that can adopt different conformations and biological properties. Recently,...