Ellen Gerhardt
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Explore the profile of Ellen Gerhardt including associated specialties, affiliations and a list of published articles.
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41
Citations
1177
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Recent Articles
1.
Soares E, Queiroz L, Gerhardt E, Prediger R, Outeiro T, Cimarosti H
Mol Cell Neurosci
. 2024 Sep;
131:103969.
PMID: 39260456
SUMOylation is a post-translational modification essential for various biological processes. SUMO proteins bind to target substrates in a three-step enzymatic pathway, which is rapidly reversible by the action of specific...
2.
Oliveira da Silva M, Santejo M, Babcock I, Magalhaes A, Minamide L, Won S, et al.
Cell Death Dis
. 2024 Apr;
15(4):264.
PMID: 38615035
Cognitive dysfunction and dementia are critical symptoms of Lewy Body dementias (LBD). Specifically, alpha-synuclein (αSyn) accumulation in the hippocampus leading to synaptic dysfunction is linked to cognitive deficits in LBD....
3.
Galka D, Ali T, Bast A, Niederleithinger M, Gerhardt E, Motosugi R, et al.
Aging Cell
. 2024 Feb;
23(5):e14128.
PMID: 38415292
Parkinson's disease (PD) is characterized by aggregation of α-synuclein (α-syn) into protein inclusions in degenerating brains. Increasing amounts of aggregated α-syn species indicate significant perturbation of cellular proteostasis. Altered proteostasis...
4.
Xylaki M, Paiva I, Al-Azzani M, Gerhardt E, Jain G, Islam M, et al.
J Parkinsons Dis
. 2023 Feb;
13(2):179-196.
PMID: 36744345
Background: Synucleinopathies are disorders characterized by the abnormal accumulation of α-synuclein (aSyn). Synaptic compromise is observed in synucleinopathies parallel to aSyn aggregation and is accompanied by transcript deregulation. Objective: We...
5.
Hassanzadeh K, Morrone C, Akhtari K, Gerhardt E, Zaccagnini L, Outeiro T, et al.
Mech Ageing Dev
. 2022 Dec;
209:111759.
PMID: 36464085
The exon skipping of α-Synuclein (α-Syn), the main constituent of the abnormal protein aggregation in Lewy bodies of Parkinson's disease (PD), forms four isoforms. In contrast to the full length...
6.
Bras I, Khani M, Vasili E, Mobius W, Riedel D, Parfentev I, et al.
J Parkinsons Dis
. 2022 Oct;
12(8):2397-2422.
PMID: 36278361
Background: Various cellular pathways have been implicated in the transfer of disease-related proteins between cells, contributing to disease progression and neurodegeneration. However, the overall effects of protein transfer are still...
7.
Bras I, Khani M, Riedel D, Parfentev I, Gerhardt E, van Riesen C, et al.
J Proteomics
. 2022 Sep;
269:104721.
PMID: 36089191
Extracellular vesicles (EVs) are important mediators in intercellular communication. However, understanding the biological origin and functional effects of EVs subtypes has been challenging due to the moderate differences in their...
8.
Queiroz D, Ribeiro T, Goncalves J, Mattos L, Gerhardt E, Freitas J, et al.
Biochim Biophys Acta Mol Basis Dis
. 2022 Jul;
1868(10):166475.
PMID: 35777688
The overproduction of reactive oxygen species (ROS) induces oxidative stress, a well-known process associated with aging and several human pathologies, such as cancer and neurodegenerative diseases. A large number of...
9.
Torres-Garcia L, P Domingues J, Brandi E, Haikal C, Mudannayake J, Bras I, et al.
Sci Rep
. 2022 Feb;
12(1):2987.
PMID: 35194057
Parkinson's disease (PD) and Alzheimer's disease (AD) are characterized by pathological accumulation and aggregation of different amyloidogenic proteins, α-synuclein (aSyn) in PD, and amyloid-β (Aβ) and Tau in AD. Strikingly,...
10.
Bras I, Dominguez-Meijide A, Gerhardt E, Koss D, Lazaro D, Santos P, et al.
J Neurochem
. 2020 Jan;
153(4):433-454.
PMID: 31957016
Synucleinopathies are a group of disorders characterized by the accumulation of inclusions rich in the a-synuclein (aSyn) protein. This group of disorders includes Parkinson's disease, dementia with Lewy bodies (DLB),...