Luciano Galdieri
Overview
Explore the profile of Luciano Galdieri including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
481
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Recent Articles
1.
Galdieri L, Jash A, Malkova O, Mao D, DeSouza P, Chu Y, et al.
JCI Insight
. 2021 Jan;
6(4).
PMID: 33400685
Most patients with glioblastoma (GBM) die within 2 years. A major therapeutic goal is to target GBM stem cells (GSCs), a subpopulation of cells that contribute to treatment resistance and...
2.
Zhang T, Galdieri L, Hasek J, Vancura A
FEMS Microbiol Lett
. 2017 Nov;
364(22).
PMID: 29087456
Phospholipase C (Plc1p) in Saccharomyces cerevisiae is required for normal degradation of repressor Mth1p and expression of the HXT genes encoding cell membrane transporters of glucose. Plc1p is also required...
3.
Galdieri L, Gatla H, Vancurova I, Vancura A
J Biol Chem
. 2016 Oct;
291(48):25154-25166.
PMID: 27733682
AMP-activated protein kinase (AMPK) is an energy sensor and master regulator of metabolism. AMPK functions as a fuel gauge monitoring systemic and cellular energy status. Activation of AMPK occurs when...
4.
Galdieri L, Zhang T, Rogerson D, Vancura A
Mol Cell Biol
. 2016 Jan;
36(7):1064-77.
PMID: 26787838
Regulation of mitochondrial biogenesis and respiration is a complex process that involves several signaling pathways and transcription factors as well as communication between the nuclear and mitochondrial genomes. Here we...
5.
Galdieri L, Zhang T, Rogerson D, Lleshi R, Vancura A
Eukaryot Cell
. 2014 Oct;
13(12):1472-83.
PMID: 25326522
Cells sense and appropriately respond to the physical conditions and availability of nutrients in their environment. This sensing of the environment and consequent cellular responses are orchestrated by a multitude...
6.
Mehrotra S, Galdieri L, Zhang T, Zhang M, Pemberton L, Vancura A
Biochim Biophys Acta
. 2014 Jun;
1839(9):751-63.
PMID: 24907648
Transcriptional activation is typically associated with increased acetylation of promoter histones. However, this paradigm does not apply to transcriptional activation of all genes. In this study we have characterized a...
7.
Zhang M, Galdieri L, Vancura A
Mol Cell Biol
. 2013 Oct;
33(23):4701-17.
PMID: 24081331
Acetyl coenzyme A (acetyl-CoA) is a key metabolite at the crossroads of metabolism, signaling, chromatin structure, and transcription. Concentration of acetyl-CoA affects histone acetylation and links intermediary metabolism and transcriptional...
8.
Galdieri L, Chang J, Mehrotra S, Vancura A
J Biol Chem
. 2013 Aug;
288(39):27986-98.
PMID: 23913687
Phospholipase C (Plc1p) is required for the initial step of inositol polyphosphate (InsP) synthesis, and yeast cells with deletion of the PLC1 gene are completely devoid of any InsPs and...
9.
Galdieri L, Vancura A
J Biol Chem
. 2012 May;
287(28):23865-76.
PMID: 22580297
Histone acetylation depends on intermediary metabolism for supplying acetyl-CoA in the nucleocytosolic compartment. However, because nucleocytosolic acetyl-CoA is also used for de novo synthesis of fatty acids, histone acetylation and...
10.
Galdieri L, Desai P, Vancura A
J Mol Biol
. 2011 Dec;
415(3):464-74.
PMID: 22137896
Mediator is a general coactivator of RNA polymerase II (RNA pol II) bridging enhancer-bound transcriptional factors with RNA pol II. Mediator is organized in three distinct subcomplexes: head, middle, and...