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Lucia Wickert

Explore the profile of Lucia Wickert including associated specialties, affiliations and a list of published articles. Areas
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Articles 9
Citations 204
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Recent Articles
1.
Johnen S, Wickert L, Meier M, Salz A, Walter P, Thumann G
Invest Ophthalmol Vis Sci . 2011 Jan; 52(5):2817-24. PMID: 21220557
Purpose: Mitotically inhibited 3T3 fibroblasts are used as feeder layers to culture a variety of cells. However, transplantation of human cells cultured on mitotically arrested mouse cells poses potential risks,...
2.
Denecke B, Wickert L, Liu Y, Ciuclan L, Dooley S, Meindl-Beinker N
World J Gastroenterol . 2010 Nov; 16(41):5211-24. PMID: 21049555
Aim: To analyse the influence of Smad7, antagonist of transforming growth factor (TGF)-β canonical signaling pathways on hepatic stellate cell (HSC) transdifferentiation in detail. Methods: We systematically analysed genes regulated...
3.
Wickert L, Chatain N, Kruschinsky K, Gressner A
Comp Hepatol . 2007 May; 6:5. PMID: 17474984
Background: In addition to the activation of hepatic stellate cells TGF-beta govern apoptosis and growth control of hepatocytes in liver injury. In non-parenchymal cells, TGF-beta induces plasminogen activator inhibitor 1...
4.
Wiercinska E, Wickert L, Denecke B, Said H, Hamzavi J, Gressner A, et al.
Hepatology . 2006 Apr; 43(5):1032-41. PMID: 16628634
Transforming growth factor (TGF)-beta is critically involved in the activation of hepatic stellate cells (HSCs) that occurs during the process of liver damage, for example, by alcohol, hepatotoxic viruses, or...
5.
Breitkopf K, van Roeyen C, Sawitza I, Wickert L, Floege J, Gressner A
Cytokine . 2005 Jul; 31(5):349-57. PMID: 16039137
The platelet-derived growth factor (PDGF) family, which regulates many physiological and pathophysiological processes has recently been enlarged by two new members, the isoforms PDGF-C and -D. Little is known about...
6.
Lindert S, Wickert L, Sawitza I, Wiercinska E, Gressner A, Dooley S, et al.
Matrix Biol . 2005 May; 24(3):198-207. PMID: 15905080
Hepatic stellate cells (HSC) cultured on plastic spontaneously transdifferentiate to a myofibroblast-like cell type (MFB). This model system of hepatic fibrogenesis is characterized by phenotypic changes of the cells and...
7.
Kopp J, Preis E, Said H, Hafemann B, Wickert L, Gressner A, et al.
J Biol Chem . 2005 Mar; 280(22):21570-6. PMID: 15788410
Human fibroproliferative disorders like hypertrophic scarring of the skin are characterized by increased contractility and excess extracellular matrix synthesis. A beneficial role of transforming growth factor (TGF)-beta in wound healing...
8.
Bolkenius U, Hahn D, Gressner A, Breitkopf K, Dooley S, Wickert L
Biochem Biophys Res Commun . 2004 Nov; 325(4):1264-70. PMID: 15555563
Glucocorticoids bound to their receptors transmit information, which regulates numerous physiological and pathophysiological responses, amongst others glucose metabolism, wound healing, inflammation, and stress, either directly as transcription factors by binding...
9.
Wickert L, Abiaka M, Bolkenius U, Gressner A
J Hepatol . 2003 Dec; 40(1):69-76. PMID: 14672616
Background/aims: Transforming growth factor (TGF)-beta receptors mediate TGF-beta signaling in activated hepatic stellate cells (HSC). This leads to pleiotropic cellular effects, e.g. to the production of extracellular matrix which is...