Katja Breitkopf
Overview
Explore the profile of Katja Breitkopf including associated specialties, affiliations and a list of published articles.
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18
Citations
977
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Recent Articles
1.
TGF-beta enhances alcohol dependent hepatocyte damage via down-regulation of alcohol dehydrogenase I
Ciuclan L, Ehnert S, Ilkavets I, Weng H, Gaitantzi H, Tsukamoto H, et al.
J Hepatol
. 2010 Feb;
52(3):407-16.
PMID: 20129692
Background & Aims: Adverse alcohol effects in the liver involve oxidative metabolism, fat deposition and release of fibrogenic mediators, including TGF-beta. The work presents an assessment of liver damaging cross-talk...
2.
Mleczko-Sanecka K, Casanovas G, Ragab A, Breitkopf K, Muller A, Boutros M, et al.
Blood
. 2009 Dec;
115(13):2657-65.
PMID: 20040761
Hepcidin is the master regulatory hormone of systemic iron metabolism. Hepcidin deficiency causes common iron overload syndromes whereas its overexpression is responsible for microcytic anemias. Hepcidin transcription is activated by...
3.
Breitkopf K, Nagy L, Beier J, Mueller S, Weng H, Dooley S
Alcohol Clin Exp Res
. 2009 Aug;
33(10):1647-55.
PMID: 19645734
Chronic alcohol abuse is an important cause of morbidity and mortality throughout the world. Liver damage due to chronic alcohol intoxication initially leads to accumulation of lipids within the liver...
4.
Haas S, Fitzner B, Jaster R, Wiercinska E, Gaitantzi H, Jesnowski R, et al.
Growth Factors
. 2009 Jul;
27(5):289-99.
PMID: 19639490
Nerve growth factor (NGF), a survival factor for neurons enforces pain by sensitizing nociceptors. Also in the pancreas, NGF was associated with pain and it can stimulate the proliferation of...
5.
Dooley S, Hamzavi J, Ciuclan L, Godoy P, Ilkavets I, Ehnert S, et al.
Gastroenterology
. 2008 Jul;
135(2):642-59.
PMID: 18602923
Background & Aims: The profibrogenic role of transforming growth factor (TGF)-beta in liver has mostly been attributed to hepatic stellate cell activation and excess matrix synthesis. Hepatocytes are believed to...
6.
Weng H, Ciuclan L, Liu Y, Hamzavi J, Godoy P, Gaitantzi H, et al.
Hepatology
. 2007 Jul;
46(4):1257-70.
PMID: 17657819
Unlabelled: Connective tissue growth factor (CTGF) is important for transforming growth factor-beta (TGF-beta)-induced liver fibrogenesis. Hepatic stellate cells have been recognized as its major cellular source in the liver. Here...
7.
Subotic U, Hannmann T, Kiss M, Brade J, Breitkopf K, Loff S
J Pediatr Gastroenterol Nutr
. 2007 Jan;
44(1):71-6.
PMID: 17204957
Objectives: Except for polyadipate, which is used as an alternative in polyvinylchloride (PVC) feeding tubes, diethylhexylphthalate (DEHP) is the plasticizer used almost exclusively in PVC medical products. A clear response...
8.
Seyhan H, Hamzavi J, Wiercinska E, Gressner A, Mertens P, Kopp J, et al.
J Cell Mol Med
. 2006 Nov;
10(4):922-32.
PMID: 17125595
Background/aims: Profibrogenic TGF-beta signaling in hepatic stellate cells is modulated during transdifferentiation. Strategies to abrogate TGF-beta effects provide promising antifibrotic results, however, in vivo data regarding Smad activation during fibrogenesis...
9.
Wiercinska E, Wickert L, Denecke B, Said H, Hamzavi J, Gressner A, et al.
Hepatology
. 2006 Apr;
43(5):1032-41.
PMID: 16628634
Transforming growth factor (TGF)-beta is critically involved in the activation of hepatic stellate cells (HSCs) that occurs during the process of liver damage, for example, by alcohol, hepatotoxic viruses, or...
10.
Breitkopf K, Haas S, Wiercinska E, Singer M, Dooley S
Alcohol Clin Exp Res
. 2005 Dec;
29(11 Suppl):121S-131S.
PMID: 16344596
Permanent alcohol abuse may lead to chronic liver injury with deleterious sequelae such as liver cirrhosis and hepatocellular carcinoma. Mechanisms of fibrogenesis encompass recruitment of inflammatory cells at the site...