Lucia M Malone
Overview
Explore the profile of Lucia M Malone including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
9
Citations
208
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Harding K, Malone L, Kyte N, Jackson S, Smith L, Fineran P
Nucleic Acids Res
. 2024 Dec;
53(3).
PMID: 39694477
The Chimalliviridae family of bacteriophages (phages) form a proteinaceous nucleus-like structure during infection of their bacterial hosts. This phage 'nucleus' compartmentalises phage DNA replication and transcription, and shields the phage...
2.
Mahler M, Malone L, van den Berg D, Smith L, Brouns S, Fineran P
Microb Genom
. 2023 Mar;
9(3).
PMID: 36995210
sp. ATCC 39006 is a Gram-negative bacterium that has been used to study the function of phage defences, such as CRISPR-Cas, and phage counter-defence mechanisms. To expand our phage collection...
3.
Mayo-Munoz D, Smith L, Garcia-Doval C, Malone L, Harding K, Jackson S, et al.
Mol Cell
. 2022 Nov;
82(23):4471-4486.e9.
PMID: 36395770
Bacteria have diverse defenses against phages. In response, jumbo phages evade multiple DNA-targeting defenses by protecting their DNA inside a nucleus-like structure. We previously demonstrated that RNA-targeting type III CRISPR-Cas...
4.
Warring S, Malone L, Jayaraman J, Easingwood R, Rigano L, Frampton R, et al.
Environ Microbiol
. 2022 Aug;
24(10):4834-4852.
PMID: 35912527
Bacterial pathogens are major causes of crop diseases, leading to significant production losses. For instance, kiwifruit canker, caused by the phytopathogen Pseudomonas syringae pv. actinidiae (Psa), has posed a global...
5.
Malone L, Hampton H, Morgan X, Fineran P
Nucleic Acids Res
. 2021 Dec;
50(1):160-174.
PMID: 34928385
During infection, phages manipulate bacteria to redirect metabolism towards viral proliferation. To counteract phages, some bacteria employ CRISPR-Cas systems that provide adaptive immunity. While CRISPR-Cas mechanisms have been studied extensively,...
6.
Smith L, Jackson S, Malone L, Ussher J, Gardner P, Fineran P
Nat Microbiol
. 2021 Jan;
6(2):162-172.
PMID: 33398095
Bacteria harbour multiple innate defences and adaptive CRISPR-Cas systems that provide immunity against bacteriophages and mobile genetic elements. Although some bacteria modulate defences in response to population density, stress and...
7.
Malone L, Birkholz N, Fineran P
Curr Opin Biotechnol
. 2020 Oct;
68:30-36.
PMID: 33113496
The rise of antibiotic-resistant bacteria has led to renewed interest in the use of their natural enemies, phages, for the prevention and treatment of infections. However, phage therapy requires detailed...
8.
Malone L, Warring S, Jackson S, Warnecke C, Gardner P, Gumy L, et al.
Nat Microbiol
. 2019 Dec;
5(1):48-55.
PMID: 31819217
CRISPR-Cas systems provide bacteria with adaptive immunity against bacteriophages. However, DNA modification, the production of anti-CRISPR proteins and potentially other strategies enable phages to evade CRISPR-Cas. Here, we discovered a...
9.
Jackson S, Birkholz N, Malone L, Fineran P
Cell Host Microbe
. 2019 Jan;
25(2):250-260.e4.
PMID: 30661951
Many prokaryotes possess CRISPR-Cas adaptive immune systems to defend against viruses and invading mobile genetic elements. CRISPR-Cas immunity relies on genetic memories, termed spacers, for sequence-specific recognition of infections. The...