Lucia Echevarria
Overview
Explore the profile of Lucia Echevarria including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
363
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Recent Articles
1.
Echevarria L, Goyenvalle A
Methods Mol Biol
. 2022 Feb;
2434:371-384.
PMID: 35213032
Antisense oligonucleotides (ASO) therapeutics hold great promise for the treatment of numerous diseases, and several ASO drugs have now reached market approval, confirming the potential of this approach. However, some...
2.
Relizani K, Echevarria L, Zarrouki F, Gastaldi C, Dambrune C, Aupy P, et al.
Nucleic Acids Res
. 2021 Dec;
50(1):17-34.
PMID: 34893881
Tricyclo-DNA (tcDNA) is a conformationally constrained oligonucleotide analog that has demonstrated great therapeutic potential as antisense oligonucleotide (ASO) for several diseases. Like most ASOs in clinical development, tcDNA were modified...
3.
Hammond S, Aartsma-Rus A, Alves S, Borgos S, Buijsen R, Collin R, et al.
EMBO Mol Med
. 2021 Apr;
13(4):e13243.
PMID: 33821570
Nucleic acid-based therapeutics that regulate gene expression have been developed towards clinical use at a steady pace for several decades, but in recent years the field has been accelerating. To...
4.
Echevarria L, Malerba A, Arechavala-Gomeza V
Nucleic Acid Ther
. 2020 Jul;
31(3):185-189.
PMID: 32730128
Scientific advance is based on reproducibility, corroboration, and availability of research results. However, large numbers of experimental results that contradict previous work do not get published and many research results...
5.
Aupy P, Echevarria L, Relizani K, Zarrouki F, Haeberli A, Komisarski M, et al.
Mol Ther Nucleic Acids
. 2019 Dec;
19:371-383.
PMID: 31881528
Tricyclo-DNA (tcDNA) antisense oligonucleotides (ASOs) hold promise for therapeutic splice-switching applications and the treatment of Duchenne muscular dystrophy (DMD) in particular. We have previously reported the therapeutic potential of tcDNA-ASO...
6.
Echevarria L, Aupy P, Relizani K, Bestetti T, Griffith G, Blandel F, et al.
Nucleic Acid Ther
. 2019 Apr;
29(3):148-160.
PMID: 31009315
Antisense oligonucleotides (ASOs) hold promise for therapeutic splice switching correction for genetic diseases, in particular for Duchenne muscular dystrophy (DMD), for which ASO-exon skipping represents one of the most advanced...
7.
Echevarria L, Aupy P, Goyenvalle A
Hum Mol Genet
. 2018 May;
27(R2):R163-R172.
PMID: 29771317
Duchenne muscular dystrophy (DMD) is a fatal genetic disorder characterized by progressive muscle wasting that has currently no cure. Exon-skipping strategy represents one of the most promising therapeutic approaches that...
8.
Aupy P, Echevarria L, Relizani K, Goyenvalle A
Biomedicines
. 2017 Dec;
6(1).
PMID: 29271929
Antisense Oligonucleotides (ASOs) represent very attractive therapeutic compounds for the treatment of numerous diseases. The antisense field has remarkably progressed over the last few years with the approval of the...
9.
Relizani K, Griffith G, Echevarria L, Zarrouki F, Facchinetti P, Vaillend C, et al.
Mol Ther Nucleic Acids
. 2017 Sep;
8:144-157.
PMID: 28918017
Antisense oligonucleotides (AONs) hold promise for therapeutic splice-switching correction in many genetic diseases. However, despite advances in AON chemistry and design, systemic use of AONs is limited due to poor...
10.
Auray-Blais C, Blais C, Ramaswami U, Boutin M, Germain D, Dyack S, et al.
Clin Chim Acta
. 2014 Aug;
438:195-204.
PMID: 25149322
Background: Fabry disease is an X-linked lysosomal storage disorder affecting both males and females with tremendous genotypic/phenotypic variability. Concentrations of globotriaosylceramide (Gb3), globotriaosylsphingosine (lyso-Gb3)/related analogues were investigated in pediatric and...