Lucas Seninge
Overview
Explore the profile of Lucas Seninge including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
8
Citations
162
Followers
0
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Yang Y, McCullough C, Seninge L, Guo L, Kwon W, Zhang Y, et al.
Dev Cell
. 2025 Jan;
PMID: 39798574
Human pluripotent stem cell-derived tissue engineering offers great promise for designer cell-based personalized therapeutics, but harnessing such potential requires a deeper understanding of tissue-level interactions. We previously developed a cell...
2.
Maulding N, Seninge L, Stuart J
Genome Biol
. 2024 Aug;
25(1):220.
PMID: 39143494
Inferring gene regulatory networks from single-cell RNA-sequencing trajectories has been an active area of research yet methods are still needed to identify regulators governing cell transitions. We developed DREAMIT (Dynamic...
3.
Yang Y, Seninge L, Wang Z, Oro A, Stuart J, Ding H
Sci Rep
. 2024 May;
14(1):11794.
PMID: 38782963
We present the Manatee variational autoencoder model to predict transcription factor (TF) perturbation-induced transcriptomes. We demonstrate that the Manatee in silico perturbation analysis recapitulates target transcriptomic phenotypes in diverse cellular...
4.
Yang Y, McCullough C, Seninge L, Guo L, Kwon W, Zhang Y, et al.
bioRxiv
. 2023 Nov;
PMID: 37961271
Human pluripotent stem cell-derived tissue engineering offers great promise in designer cell-based personalized therapeutics. To harness such potential, a broader approach requires a deeper understanding of tissue-level interactions. We previously...
5.
Robinson E, Worthington A, Poscablo D, Shapleigh B, Salih M, Halasz H, et al.
J Immunol
. 2022 Apr;
208(8):1886-1900.
PMID: 35365562
Our respiratory system is vital to protect us from the surrounding nonsterile environment; therefore, it is critical for a state of homeostasis to be maintained through a balance of inflammatory...
6.
Seninge L, Anastopoulos I, Ding H, Stuart J
Nat Commun
. 2021 Sep;
12(1):5684.
PMID: 34584103
Deep learning architectures such as variational autoencoders have revolutionized the analysis of transcriptomics data. However, the latent space of these variational autoencoders offers little to no interpretability. To provide further...
7.
Speir M, Bhaduri A, Markov N, Moreno P, Nowakowski T, Papatheodorou I, et al.
Bioinformatics
. 2021 Jul;
37(23):4578-4580.
PMID: 34244710
Summary: As the use of single-cell technologies has grown, so has the need for tools to explore these large, complicated datasets. The UCSC Cell Browser is a tool that allows...
8.
Ding H, Yang Y, Xue Y, Seninge L, Gong H, Safavi R, et al.
iScience
. 2021 Jan;
24(1):102017.
PMID: 33490923
Biological states are controlled by orchestrated transcriptional factors (TFs) within gene regulatory networks. Here we show TFs responsible for the dynamic changes of biological states can be prioritized with temporal...
9.
Sanders L, Cheney A, Seninge L, van den Bout A, Chen M, Beale H, et al.
Gigascience
. 2020 Dec;
9(12).
PMID: 33319914
Background: Diffuse midline gliomas with histone H3 K27M (H3K27M) mutations occur in early childhood and are marked by an invasive phenotype and global decrease in H3K27me3, an epigenetic mark that...