Lucas K Smith
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Explore the profile of Lucas K Smith including associated specialties, affiliations and a list of published articles.
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15
Citations
1583
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Recent Articles
1.
Schroer A, Ventura P, Sucharov J, Misra R, Chui M, Bieri G, et al.
Nature
. 2023 Aug;
620(7976):1071-1079.
PMID: 37587343
Identifying therapeutics to delay, and potentially reverse, age-related cognitive decline is critical in light of the increased incidence of dementia-related disorders forecasted in the growing older population. Here we show...
2.
Pratt K, Shea J, Remesal-Gomez L, Bieri G, Smith L, Couthouis J, et al.
Cell Rep
. 2023 Jan;
42(2):111926.
PMID: 36719799
No abstract available.
3.
Pratt K, Shea J, Remesal-Gomez L, Bieri G, Smith L, Couthouis J, et al.
Cell Rep
. 2022 Nov;
41(6):111612.
PMID: 36351399
DNA methylation has emerged as a critical modulator of neuronal plasticity and cognitive function. Notwithstanding, the role of enzymes that demethylate DNA remain to be fully explored. Here, we report...
4.
Lin K, Bieri G, Gontier G, Muller S, Smith L, Snethlage C, et al.
PLoS Biol
. 2021 Jun;
19(6):e3001311.
PMID: 34181639
Proteins of the major histocompatibility complex class I (MHC I), predominantly known for antigen presentation in the immune system, have recently been shown to be necessary for developmental neural refinement...
5.
Ho T, Dellorusso P, Verovskaya E, Bakker S, Flach J, Smith L, et al.
J Exp Med
. 2021 May;
218(7).
PMID: 34032859
While young blood can restore many aged tissues, its effects on the aged blood system itself and old hematopoietic stem cells (HSCs) have not been determined. Here, we used transplantation,...
6.
Smith L, Verovskaya E, Bieri G, Horowitz A, von Ungern-Sternberg S, Lin K, et al.
Aging Cell
. 2020 Oct;
19(8):e13192.
PMID: 33073926
The aged systemic milieu promotes cellular and cognitive impairments in the hippocampus. Here, we report that aging of the hematopoietic system directly contributes to the pro-aging effects of old blood...
7.
Horowitz A, Fan X, Bieri G, Smith L, Sanchez-Diaz C, Schroer A, et al.
Science
. 2020 Jul;
369(6500):167-173.
PMID: 32646997
Reversing brain aging may be possible through systemic interventions such as exercise. We found that administration of circulating blood factors in plasma from exercised aged mice transferred the effects of...
8.
Nguyen Q, Witt R, Wang B, Eikani C, Shea J, Smith L, et al.
Sci Transl Med
. 2020 Feb;
12(532).
PMID: 32102934
Mucopolysaccharidosis type VII (MPS7) is a lysosomal storage disorder (LSD) resulting from mutations in the β-glucuronidase gene, leading to multiorgan dysfunction and fetal demise. While postnatal enzyme replacement therapy (ERT)...
9.
Schneider C, Lee J, Koga S, Ricardo-Gonzalez R, Nussbaum J, Smith L, et al.
Immunity
. 2019 May;
50(6):1425-1438.e5.
PMID: 31128962
The perinatal period is a critical window for distribution of innate tissue-resident immune cells within developing organs. Despite epidemiologic evidence implicating the early-life environment in the risk for allergy, temporally...
10.
Smith L, White 3rd C, Villeda S
Cell Tissue Res
. 2017 Nov;
371(1):105-113.
PMID: 29124393
Aging results in impaired neurogenesis in the two neurogenic niches of the adult mammalian brain, the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricle. While...