Lotte P Watts
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Explore the profile of Lotte P Watts including associated specialties, affiliations and a list of published articles.
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4
Citations
102
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Recent Articles
1.
Jones T, Feng J, Luyties O, Cozzolino K, Sanford L, Rimel J, et al.
Sci Adv
. 2025 Feb;
11(9):eadr9660.
PMID: 40020069
How cyclin-dependent kinase 7 (CDK7) coordinately regulates the cell cycle and RNA polymerase II transcription remains unclear. Here, high-resolution cryo-electron microscopy revealed how two clinically relevant inhibitors block CDK7 function....
2.
Luyties O, Sanford L, Rodino J, Nagel M, Jones T, Rimel J, et al.
bioRxiv
. 2025 Jan;
PMID: 39829884
CDK7 regulates RNA polymerase II (RNAPII) initiation, elongation, and termination through incompletely understood mechanisms. Because contaminating kinases precluded CDK7 analysis with nuclear extracts, we completed biochemical assays with purified factors....
3.
Watts L, Spencer S
Cancer Discov
. 2024 Mar;
14(3):386-388.
PMID: 38426558
In this issue, Dietrich, Trub, and colleagues describe and characterize a novel selective CDK2 inhibitor: INX-315. This agent shows promise in CCNE1-amplified cancers and in CDK4/6 inhibitor-resistant breast cancers. See...
4.
Arora M, Moser J, Hoffman T, Watts L, Min M, Musteanu M, et al.
Cell
. 2023 Jun;
186(12):2628-2643.e21.
PMID: 37267950
CDK2 is a core cell-cycle kinase that phosphorylates many substrates to drive progression through the cell cycle. CDK2 is hyperactivated in multiple cancers and is therefore an attractive therapeutic target....
5.
Klein K, Zhao P, Lyu X, Sasaki T, Bartlett D, Singh A, et al.
Science
. 2021 Apr;
372(6540):371-378.
PMID: 33888635
The temporal order of DNA replication [replication timing (RT)] is correlated with chromatin modifications and three-dimensional genome architecture; however, causal links have not been established, largely because of an inability...
6.
Watts L, Natsume T, Saito Y, Garzon J, Dong Q, Boteva L, et al.
Elife
. 2020 Nov;
9.
PMID: 33141022
Human cells lacking RIF1 are highly sensitive to replication inhibitors, but the reasons for this sensitivity have been enigmatic. Here, we show that RIF1 must be present both during replication...