Olivia Luyties
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Explore the profile of Olivia Luyties including associated specialties, affiliations and a list of published articles.
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4
Citations
103
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Recent Articles
1.
Jones T, Feng J, Luyties O, Cozzolino K, Sanford L, Rimel J, et al.
Sci Adv
. 2025 Feb;
11(9):eadr9660.
PMID: 40020069
How cyclin-dependent kinase 7 (CDK7) coordinately regulates the cell cycle and RNA polymerase II transcription remains unclear. Here, high-resolution cryo-electron microscopy revealed how two clinically relevant inhibitors block CDK7 function....
2.
Luyties O, Sanford L, Rodino J, Nagel M, Jones T, Rimel J, et al.
bioRxiv
. 2025 Jan;
PMID: 39829884
CDK7 regulates RNA polymerase II (RNAPII) initiation, elongation, and termination through incompletely understood mechanisms. Because contaminating kinases precluded CDK7 analysis with nuclear extracts, we completed biochemical assays with purified factors....
3.
Luyties O, Taatjes D
Trends Biochem Sci
. 2022 Feb;
47(4):314-327.
PMID: 35193797
The Mediator complex controls RNA polymerase II (pol II) activity by coordinating the assembly of pol II regulatory factors at transcription start sites and by mediating interactions between enhancer-bound transcription...
4.
Tomko E, Luyties O, Rimel J, Tsai C, Fuss J, Fishburn J, et al.
J Mol Biol
. 2021 Jan;
433(14):166813.
PMID: 33453189
The general transcription factor TFIIH contains three ATP-dependent catalytic activities. TFIIH functions in nucleotide excision repair primarily as a DNA helicase and in Pol II transcription initiation as a dsDNA...
5.
Fant C, Levandowski C, Gupta K, Maas Z, Moir J, Rubin J, et al.
Mol Cell
. 2020 Apr;
78(4):785-793.e8.
PMID: 32229306
RNA polymerase II (RNAPII) transcription is governed by the pre-initiation complex (PIC), which contains TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, RNAPII, and Mediator. After initiation, RNAPII enzymes pause after transcribing...
6.
Walker J, Luyties O, Santangelo T
Proc Natl Acad Sci U S A
. 2017 Aug;
114(33):E6767-E6773.
PMID: 28760969
RNA polymerase activity is regulated by nascent RNA sequences, DNA template sequences, and conserved transcription factors. Transcription factors promoting initiation and elongation have been characterized in each domain, but transcription...