Lorraine A Lebel
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Explore the profile of Lorraine A Lebel including associated specialties, affiliations and a list of published articles.
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7
Citations
517
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Recent Articles
1.
ODonnell C, Peng L, ONeill B, Arnold E, Mather R, Sands S, et al.
Bioorg Med Chem Lett
. 2009 Jul;
19(16):4747-51.
PMID: 19576766
The synthesis and SAR studies about the bicyclic amine, carbamate linker and aromatic ring of a 1,4-diazabicyclo[3.2.2]nonane phenyl carbamate series of alpha7 nAChR agonists is described. The development of the...
2.
Yohannes D, Procko K, Lebel L, Fox C, ONeill B
Bioorg Med Chem Lett
. 2008 Mar;
18(7):2316-9.
PMID: 18356044
A novel fused tricyclic analog (11) of cytisine has been prepared (coined 'cyfusine') and determined to have high affinity at neuronal nicotinic acetylcholine receptors. A [3+2] cycloaddition protocol permitted entry...
3.
Chappie T, Humphrey J, Allen M, Estep K, Fox C, Lebel L, et al.
J Med Chem
. 2007 Jan;
50(2):182-5.
PMID: 17228859
A papaverine based pharmacophore model for PDE10A inhibition was generated via SBDD and used to design a library of 4-amino-6,7-dimethoxyquinazolines. From this library emerged an aryl ether pyrrolidyl 6,7-dimethoxyquinazoline series...
4.
Siuciak J, Chapin D, Harms J, Lebel L, McCarthy S, Chambers L, et al.
Neuropharmacology
. 2006 Jun;
51(2):386-96.
PMID: 16780899
Phosphodiesterase 10A (PDE10A) is a recently identified cyclic nucleotide phosphodiesterase expressed primarily in dopaminoreceptive medium spiny neurons of the striatum. We report that papaverine is a potent, specific inhibitor of...
5.
Coe J, Brooks P, Wirtz M, Bashore C, Bianco K, Vetelino M, et al.
Bioorg Med Chem Lett
. 2005 Sep;
15(22):4889-97.
PMID: 16171993
3,5-Bicyclic aryl piperidines are a new class of high-affinity alpha4beta2 nicotinic receptor agents. We have sought nicotinic receptor partial agonists of the alpha4beta2 nicotinic acetylcholine receptor for smoking cessation, and...
6.
Coe J, Vetelino M, Bashore C, Wirtz M, Brooks P, Arnold E, et al.
Bioorg Med Chem Lett
. 2005 May;
15(12):2974-9.
PMID: 15908213
The preparation and biological activity of analogs of (-)-cytisine, an alpha4beta2 nicotinic receptor partial agonist, are discussed. All-carbon-containing phenyl ring replacements of the pyridone ring system, generated via Heck cyclization...
7.
Coe J, Brooks P, Vetelino M, Wirtz M, Arnold E, Huang J, et al.
J Med Chem
. 2005 May;
48(10):3474-7.
PMID: 15887955
Herein we describe a novel series of compounds from which varenicline (1, 6,7,8,9-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine) has been identified for smoking cessation. Neuronal nicotinic acetylcholine receptors (nAChRs) mediate the dependence-producing effects of nicotine....