Alka Shrikhande
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Explore the profile of Alka Shrikhande including associated specialties, affiliations and a list of published articles.
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7
Citations
515
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Recent Articles
1.
Lowe 3rd J, DeNinno S, Coe J, Zhang L, Mente S, Hurst R, et al.
Bioorg Med Chem Lett
. 2010 Jul;
20(16):4749-52.
PMID: 20663668
We report the synthesis of a series of [3.2.1]azabicyclic biaryl ethers as selective agonists of alpha3- and alpha6-containing nicotinic receptors. In particular, compound 17a from this series is a potent...
2.
Nadanaciva S, Dillman K, Gebhard D, Shrikhande A, Will Y
J Biomol Screen
. 2010 Jul;
15(8):937-48.
PMID: 20625181
Compounds that interfere with the synthesis of either mitochondrial DNA or mtDNA-encoded proteins reduce the levels of 13 proteins essential for oxidative phosphorylation, leading to a decrease in mitochondrial adenosine...
3.
ODonnell C, Peng L, ONeill B, Arnold E, Mather R, Sands S, et al.
Bioorg Med Chem Lett
. 2009 Jul;
19(16):4747-51.
PMID: 19576766
The synthesis and SAR studies about the bicyclic amine, carbamate linker and aromatic ring of a 1,4-diazabicyclo[3.2.2]nonane phenyl carbamate series of alpha7 nAChR agonists is described. The development of the...
4.
Rollema H, Guanowsky V, Mineur Y, Shrikhande A, Coe J, Seymour P, et al.
Eur J Pharmacol
. 2009 Jan;
605(1-3):114-6.
PMID: 19168054
Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist developed as a smoking cessation aid, showed antidepressant-like activity in the forced swim test in two mouse strains. In addition, a low...
5.
Siuciak J, Chapin D, Harms J, Lebel L, McCarthy S, Chambers L, et al.
Neuropharmacology
. 2006 Jun;
51(2):386-96.
PMID: 16780899
Phosphodiesterase 10A (PDE10A) is a recently identified cyclic nucleotide phosphodiesterase expressed primarily in dopaminoreceptive medium spiny neurons of the striatum. We report that papaverine is a potent, specific inhibitor of...
6.
Coe J, Brooks P, Vetelino M, Wirtz M, Arnold E, Huang J, et al.
J Med Chem
. 2005 May;
48(10):3474-7.
PMID: 15887955
Herein we describe a novel series of compounds from which varenicline (1, 6,7,8,9-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine) has been identified for smoking cessation. Neuronal nicotinic acetylcholine receptors (nAChRs) mediate the dependence-producing effects of nicotine....
7.
Dumas J, Hatoum-Mokdad H, Sibley R, Smith R, Scott W, Khire U, et al.
Bioorg Med Chem Lett
. 2002 Jun;
12(12):1559-62.
PMID: 12039561
Inhibitors of the MAP kinase p38 provide a novel approach for the treatment of osteoporosis, inflammatory disorders, and cancer. We have identified N-(3-tert-butyl-1-methyl-5-pyrazolyl)-N'-(4-(4-pyridinylmethyl)phenyl)urea as a potent and selective p38 kinase...