Lisa Murray-Segal
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Explore the profile of Lisa Murray-Segal including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
205
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Recent Articles
1.
Katerelos M, Gleich K, Harley G, Loh K, Oakhill J, Kemp B, et al.
Biomed Pharmacother
. 2024 May;
175:116730.
PMID: 38749175
Acute kidney injury (AKI) disrupts energy metabolism. Targeting metabolism through AMP-activated protein kinase (AMPK) may alleviate AKI. ATX-304, a pan-AMPK activator, was evaluated in C57Bl/6 mice and tubular epithelial cell...
2.
Neopane K, Kozlov N, Negoita F, Murray-Segal L, Brink R, Hoque A, et al.
Cell Rep
. 2022 Dec;
41(12):111862.
PMID: 36543129
AMP-activated protein kinase (AMPK) is a master regulator of cellular energy homeostasis and a therapeutic target for metabolic diseases. Co/post-translational N-myristoylation of glycine-2 (Gly2) of the AMPK β subunit has...
3.
Janzen N, Whitfield J, Murray-Segal L, Kemp B, Hawley J, Hoffman N
Front Physiol
. 2022 Apr;
13:859246.
PMID: 35392375
The AMP-activated protein kinase (AMPK) is a central regulator of cellular energy balance and metabolism and binds glycogen, the primary storage form of glucose in liver and skeletal muscle. The...
4.
Morrison K, Smiles W, Ling N, Hoque A, Shea G, Ngoei K, et al.
Cell Rep
. 2022 Feb;
38(7):110365.
PMID: 35172150
AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin complex 1 (mTORC1) are metabolic kinases that co-ordinate nutrient supply with cell growth. AMPK negatively regulates mTORC1, and mTORC1 reciprocally phosphorylates...
5.
Janzen N, Whitfield J, Murray-Segal L, Kemp B, Hawley J, Hoffman N
Int J Mol Sci
. 2021 Sep;
22(17).
PMID: 34502525
The AMP-activated protein kinase (AMPK), a central regulator of cellular energy balance and metabolism, binds glycogen via its β subunit. However, the physiological effects of disrupting AMPK-glycogen interactions remain incompletely...
6.
Hoffman N, Whitfield J, Janzen N, Belhaj M, Galic S, Murray-Segal L, et al.
Mol Metab
. 2020 Jul;
41:101048.
PMID: 32610071
Objective: Glycogen is a major energy reserve in liver and skeletal muscle. The master metabolic regulator AMP-activated protein kinase (AMPK) associates with glycogen via its regulatory β subunit carbohydrate-binding module...
7.
Lee J, Byun W, Kang M, Han J, Moon J, Shin M, et al.
FEBS J
. 2020 Mar;
287(10):2087-2104.
PMID: 32196931
Meteorin-like (metrnl) is a recently identified adipomyokine that beneficially affects glucose metabolism; however, its underlying mechanism of action is not completely understood. We here show that the level of metrnl...
8.
Lee H, Moon J, Chung I, Chung J, Park C, Lee J, et al.
FASEB J
. 2019 Nov;
33(12):14825-14840.
PMID: 31670977
ATPase inhibitory factor 1 (IF1) is an ATP synthase-interacting protein that suppresses the hydrolysis activity of ATP synthase. In this study, we observed that the expression of IF1 was up-regulated...
9.
Loh K, Tam S, Murray-Segal L, Huynh K, Meikle P, Scott J, et al.
Hepatol Commun
. 2019 Jan;
3(1):84-98.
PMID: 30619997
Adenosine monophosphate-activated protein kinase (AMPK) regulates multiple signaling pathways involved in glucose and lipid metabolism in response to changes in hormonal and nutrient status. Cell culture studies have shown that...
10.
Galic S, Loh K, Murray-Segal L, Steinberg G, Andrews Z, Kemp B
Elife
. 2018 Feb;
7.
PMID: 29433631
AMP-activated protein kinase (AMPK) is a known regulator of whole-body energy homeostasis, but the downstream AMPK substrates mediating these effects are not entirely clear. AMPK inhibits fatty acid synthesis and...