Lisa McKerracher
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Explore the profile of Lisa McKerracher including associated specialties, affiliations and a list of published articles.
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28
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965
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Recent Articles
1.
Imai T, Morais A, Qin T, Sasaki Y, Erdogan T, McKerracher L, et al.
J Cereb Blood Flow Metab
. 2025 Jan;
271678X241312010.
PMID: 39763388
Rho-associated protein kinase (ROCK) inhibitors are therapeutic candidates in ischemic stroke and subarachnoid hemorrhage. However, their efficacy in intracerebral hemorrhage (ICH) is unknown. Here, we tested the efficacy of fasudil...
2.
Mulder I, Abbinanti M, Woller S, Ruschel J, Coutinho J, de Vries H, et al.
J Cereb Blood Flow Metab
. 2024 Jun;
44(11):1238-1252.
PMID: 38833563
Endothelial blood-brain barrier (BBB) dysfunction is critical in the pathophysiology of brain injury. Rho-associated protein kinase (ROCK) activation disrupts BBB integrity in the injured brain. We aimed to test the...
3.
Woller S, Ruschel J, Morquette B, Cardia J, Yan D, Holton K, et al.
iScience
. 2022 May;
25(6):104379.
PMID: 35620420
The therapeutic use of RNAi has grown but often faces several hurdles related to delivery systems, compound stability, immune activation, and on-target/off-tissue effects. Self-delivering RNAi (sdRNA) molecules do not require...
4.
Fehlings M, Chen Y, Aarabi B, Ahmad F, Anderson K, Dumont T, et al.
J Neurotrauma
. 2021 Feb;
38(15):2065-2072.
PMID: 33559524
Acute traumatic spinal cord injury (SCI) can result in severe, lifelong neurological deficits. After SCI, Rho activation contributes to collapse of axonal growth cones, failure of axonal regeneration, and neuronal...
5.
McKerracher L, Shenkar R, Abbinanti M, Cao Y, Peiper A, Liao J, et al.
Transl Stroke Res
. 2019 Aug;
11(3):365-376.
PMID: 31446620
Cavernous angioma (CA) is a vascular pathology caused by loss of function in one of the 3 CA genes (CCM1, CCM2, and CCM3) that result in rho kinase (ROCK) activation....
6.
Fehlings M, Kim K, Aarabi B, Rizzo M, Bond L, McKerracher L, et al.
J Neurotrauma
. 2018 Jan;
35(9):1049-1056.
PMID: 29316845
Traumatic spinal cord injury (SCI) is associated with a lifetime of disability stemming from loss of motor, sensory, and autonomic functions; these losses, along with increased comorbid sequelae, negatively impact...
7.
McKerracher L, Rosen K
Front Mol Neurosci
. 2015 Oct;
8:51.
PMID: 26441514
While neurons in the central nervous system (CNS) have the capacity to regenerate their axons after injury, they fail to do so, in part because regeneration is limited by growth...
8.
Bond L, Sellers J, McKerracher L
Future Med Chem
. 2015 Jun;
7(8):1039-53.
PMID: 26062400
The development of novel pharmaceutical treatments for disorders of the cerebral vasculature is a serious unmet medical need. These vascular disorders are typified by a disruption in the delicate Rho...
9.
Bond L, McKerracher L
Neural Regen Res
. 2014 Oct;
9(16):1493-7.
PMID: 25317162
Cervical spinal cord injury (SCI) results in partial to full paralysis of the upper and lower extremities. Traditional primary endpoints for acute SCI clinical trials are too broad to assess...
10.
McKerracher L, Anderson K
J Neurotrauma
. 2013 Jul;
30(21):1795-804.
PMID: 23844986
The Cethrin™ clinical trial was an open-label Phase I/IIa trial undertaken to assess the safety, tolerability, and neurological status of patients with acute spinal cord injury (SCI) who were treated...