Lisa Longato
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Explore the profile of Lisa Longato including associated specialties, affiliations and a list of published articles.
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37
Citations
1467
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Recent Articles
1.
Bottcher K, Longato L, Marrone G, Mazza G, Ghemtio L, Hall A, et al.
Am J Physiol Gastrointest Liver Physiol
. 2021 Jan;
320(4):G543-G556.
PMID: 33406006
Tumor stroma and microenvironment have been shown to affect hepatocellular carcinoma (HCC) growth, with activated hepatic stellate cells (HSC) as a major contributor in this process. Recent evidence suggests that...
2.
Zanieri F, Levi A, Montefusco D, Longato L, De Chiara F, Frenguelli L, et al.
Cells
. 2020 May;
9(5).
PMID: 32429478
In non-alcoholic steatohepatitis (NASH), many lines of investigation have reported a dysregulation in lipid homeostasis, leading to intrahepatic lipid accumulation. Recently, the role of dysfunctional sphingolipid metabolism has also been...
3.
Okina Y, Sato-Matsubara M, Matsubara T, Daikoku A, Longato L, Rombouts K, et al.
J Hepatol
. 2020 Apr;
73(4):882-895.
PMID: 32330605
Background & Aims: Cytoglobin (CYGB) is a respiratory protein that acts as a scavenger of reactive oxygen species. The molecular role of CYGB in human hepatic stellate cell (HSC) activation...
4.
Mazza G, Telese A, Al-Akkad W, Frenguelli L, Levi A, Marrali M, et al.
Cells
. 2020 Jan;
9(1).
PMID: 31905709
An altered liver microenvironment characterized by a dysregulated extracellular matrix (ECM) supports the development and progression of hepatocellular carcinoma (HCC). The development of experimental platforms able to reproduce these physio-pathological...
5.
Serrano S, Gronberg A, Longato L, Rombouts K, Kuo J, Gregory M, et al.
Cells
. 2019 Nov;
8(11).
PMID: 31717385
Hepatic fibrosis can result as a pathological response to nonalcoholic steatohepatitis (NASH). Cirrhosis, the late stage of fibrosis, has been linked to poor survival and an increased risk of developing...
6.
Marrone G, De Chiara F, Bottcher K, Levi A, Dhar D, Longato L, et al.
Hepatology
. 2018 Apr;
68(3):1140-1153.
PMID: 29663481
Conclusion: The down-regulation of v-ATPase might represent a promising target for the development of antifibrotic strategies. (Hepatology 2018).
7.
Sato-Matsubara M, Matsubara T, Daikoku A, Okina Y, Longato L, Rombouts K, et al.
J Biol Chem
. 2017 Sep;
292(46):18961-18972.
PMID: 28916723
Cytoglobin (CYGB) belongs to the mammalian globin family and is exclusively expressed in hepatic stellate cells (HSCs) in the liver. In addition to its gas-binding ability, CYGB is relevant to...
8.
Mazza G, Al-Akkad W, Telese A, Longato L, Urbani L, Robinson B, et al.
Sci Rep
. 2017 Jul;
7(1):5534.
PMID: 28717194
The development of human liver scaffolds retaining their 3-dimensional structure and extra-cellular matrix (ECM) composition is essential for the advancement of liver tissue engineering. We report the design and validation...
9.
Longato L, Andreola F, Davies S, Roberts J, Fusai G, Pinzani M, et al.
Free Radic Biol Med
. 2016 Nov;
102:162-173.
PMID: 27890721
Aims: Products of lipid oxidation, such as 4-hydroxynonenal (4-HNE), are key activators of hepatic stellate cells (HSC) to a pro-fibrogenic phenotype. Isolevuglandins (IsoLG) are a family of acyclic γ-ketoaldehydes formed...
10.
Chung W, Kim M, de la Monte S, Longato L, Carlson R, Slagle B, et al.
Cancer Lett
. 2015 Oct;
370(1):1-9.
PMID: 26433160
Background And Aims: Understanding the molecular pathogenesis of hepatocellular carcinoma (HCC) is essential to identify therapeutic targets. A hepatitis B virus (HBV) related double transgenic murine model was developed. Methods:...