Lisa E Gralinski
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Explore the profile of Lisa E Gralinski including associated specialties, affiliations and a list of published articles.
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73
Citations
10266
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Recent Articles
11.
Tostanoski L, Gralinski L, Martinez D, Schaefer A, Mahrokhian S, Li Z, et al.
J Virol
. 2021 Sep;
95(23):e0097421.
PMID: 34523968
The global COVID-19 pandemic has sparked intense interest in the rapid development of vaccines as well as animal models to evaluate vaccine candidates and to define immune correlates of protection....
12.
Sims A, Mitchell H, Gralinski L, Kyle J, Burnum-Johnson K, Lam M, et al.
mBio
. 2021 Aug;
12(4):e0157221.
PMID: 34372702
Tissue- and cell-specific expression patterns are highly variable within and across individuals, leading to altered host responses after acute virus infection. Unraveling key tissue-specific response patterns provides novel opportunities for...
13.
Menachery V, Gralinski L
J Heart Lung Transplant
. 2021 Aug;
40(10):1076-1081.
PMID: 34334300
While COVID-19 is best known as a respiratory infection, SARS-CoV-2 causes systemic disease manifestations including coagulopathies. Both dysregulated extracellular matrix remodeling pathways and circulating coagulation proteins are hallmarks of severe...
14.
Tostanoski L, Gralinski L, Martinez D, Schaefer A, Mahrokhian S, Li Z, et al.
bioRxiv
. 2021 Jun;
PMID: 34159335
Importance: We have developed a series of SARS-CoV-2 vaccines using rhesus adenovirus serotype 52 (RhAd52) vectors, which exhibits a lower seroprevalence than human and chimpanzee vectors, supporting their development as...
15.
Schafer A, Gralinski L, Leist S, Winkler E, Hampton B, Mooney M, et al.
bioRxiv
. 2021 May;
PMID: 34013261
Sarbecovirus (CoV) infections, including Severe Acute Respiratory CoV (SARS-CoV) and SARS-CoV-2, are considerable human threats. Human GWAS studies have recently identified loci associated with variation in SARS-CoV-2 susceptibility. However, genetically...
16.
Wahl A, Gralinski L, Johnson C, Yao W, Kovarova M, Dinnon 3rd K, et al.
Nature
. 2021 Feb;
591(7850):451-457.
PMID: 33561864
All coronaviruses known to have recently emerged as human pathogens probably originated in bats. Here we use a single experimental platform based on immunodeficient mice implanted with human lung tissue...
17.
Graham J, Swarts J, Leist S, Schafer A, Menachery V, Gralinski L, et al.
PLoS Pathog
. 2021 Jan;
17(1):e1009287.
PMID: 33513210
The COVID-19 pandemic has revealed that infection with SARS-CoV-2 can result in a wide range of clinical outcomes in humans. An incomplete understanding of immune correlates of protection represents a...
18.
Rappazzo C, Tse L, Kaku C, Wrapp D, Sakharkar M, Huang D, et al.
Science
. 2021 Jan;
371(6531):823-829.
PMID: 33495307
The recurrent zoonotic spillover of coronaviruses (CoVs) into the human population underscores the need for broadly active countermeasures. We employed a directed evolution approach to engineer three severe acute respiratory...
19.
Dinnon 3rd K, Leist S, Schafer A, Edwards C, Martinez D, Montgomery S, et al.
Nature
. 2021 Jan;
590(7844):E22.
PMID: 33469219
No abstract available.
20.
Rappazzo C, Tse L, Kaku C, Wrapp D, Sakharkar M, Huang D, et al.
bioRxiv
. 2020 Nov;
PMID: 33236009
The recurrent zoonotic spillover of coronaviruses (CoVs) into the human population underscores the need for broadly active countermeasures. Here, we employed a directed evolution approach to engineer three SARS-CoV-2 antibodies...