Kenneth H Dinnon 3rd
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Explore the profile of Kenneth H Dinnon 3rd including associated specialties, affiliations and a list of published articles.
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36
Citations
4932
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Recent Articles
1.
Le Pen J, Paniccia G, Kinast V, Moncada-Velez M, Ashbrook A, Bauer M, et al.
PLoS Biol
. 2024 Sep;
22(9):e3002767.
PMID: 39316623
Interferons (IFNs) play a crucial role in the regulation and evolution of host-virus interactions. Here, we conducted a genome-wide arrayed CRISPR knockout screen in the presence and absence of IFN...
2.
Dillard J, Taft-Benz S, Knight A, Anderson E, Pressey K, Parotti B, et al.
Nat Commun
. 2024 May;
15(1):3738.
PMID: 38702297
Whole virus-based inactivated SARS-CoV-2 vaccines adjuvanted with aluminum hydroxide have been critical to the COVID-19 pandemic response. Although these vaccines are protective against homologous coronavirus infection, the emergence of novel...
3.
Cruz Cisneros M, Anderson E, Hampton B, Parotti B, Sarkar S, Taft-Benz S, et al.
Vaccines (Basel)
. 2024 Jan;
12(1).
PMID: 38276675
The COVID-19 pandemic led to the rapid and worldwide development of highly effective vaccines against SARS-CoV-2. However, there is significant individual-to-individual variation in vaccine efficacy due to factors including viral...
4.
Fritch E, Mordant A, Gilbert T, Wells C, Yang X, Barker N, et al.
J Proteome Res
. 2023 Aug;
22(10):3159-3177.
PMID: 37634194
Host kinases play essential roles in the host cell cycle, innate immune signaling, the stress response to viral infection, and inflammation. Previous work has demonstrated that coronaviruses specifically target kinase...
5.
Adams L, Leist S, Dinnon 3rd K, West A, Gully K, Anderson E, et al.
Cell Rep
. 2023 Mar;
42(4):112326.
PMID: 37000623
Group 2B β-coronaviruses (sarbecoviruses) have caused regional and global epidemics in modern history. Here, we evaluate the mechanisms of cross-sarbecovirus protective immunity, currently less clear yet important for pan-sarbecovirus vaccine...
6.
Amruta N, Ismael S, Leist S, Gressett T, Srivastava A, Dinnon 3rd K, et al.
Viruses
. 2023 Jan;
15(1).
PMID: 36680154
Increasing evidence suggests that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection impacts neurological function both acutely and chronically, even in the absence of pronounced respiratory distress. Developing clinically relevant...
7.
Davis M, Voss K, Turnbull J, Gustin A, Knoll M, Muruato A, et al.
Res Sq
. 2022 Nov;
PMID: 36415465
We present a comprehensive analysis of SARS-CoV-2 infection and recovery in wild type C57BL/6 mice, demonstrating that this is an ideal model of infection and recovery that accurately phenocopies acute...
8.
Dinnon 3rd K, Leist S, Okuda K, Dang H, Fritch E, Gully K, et al.
Sci Transl Med
. 2022 Jul;
14(664):eabo5070.
PMID: 35857635
A subset of individuals who recover from coronavirus disease 2019 (COVID-19) develop post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PASC), but the mechanistic basis of PASC-associated lung...
9.
Dinnon 3rd K, Leist S, Okuda K, Dang H, Fritch E, Gully K, et al.
bioRxiv
. 2022 Feb;
PMID: 35194605
COVID-19 survivors develop post-acute sequelae of SARS-CoV-2 (PASC), but the mechanistic basis of PASC-associated lung abnormalities suffers from a lack of longitudinal samples. Mouse-adapted SARS-CoV-2 MA10 produces an acute respiratory...
10.
Hsieh C, Werner A, Leist S, Stevens L, Falconer E, Goldsmith J, et al.
Cell Rep
. 2021 Oct;
37(5):109929.
PMID: 34710354
Current coronavirus (CoV) vaccines primarily target immunodominant epitopes in the S1 subunit, which are poorly conserved and susceptible to escape mutations, thus threatening vaccine efficacy. Here, we use structure-guided protein...