Linus T-Y Tsai
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Explore the profile of Linus T-Y Tsai including associated specialties, affiliations and a list of published articles.
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13
Citations
1714
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Recent Articles
1.
Pita-Juarez Y, Karagkouni D, Kalavros N, Melms J, Niezen S, Delorey T, et al.
Genome Biol
. 2025 Mar;
26(1):56.
PMID: 40087773
Background: The molecular underpinnings of organ dysfunction in severe COVID-19 and its potential long-term sequelae are under intense investigation. To shed light on these in the context of liver function,...
2.
Pita-Juarez Y, Karagkouni D, Kalavros N, Melms J, Niezen S, Delorey T, et al.
bioRxiv
. 2022 Nov;
PMID: 36324805
The molecular underpinnings of organ dysfunction in acute COVID-19 and its potential long-term sequelae are under intense investigation. To shed light on these in the context of liver function, we...
3.
Delorey T, Ziegler C, Heimberg G, Normand R, Yang Y, Segerstolpe A, et al.
Nature
. 2021 Apr;
595(7865):107-113.
PMID: 33915569
COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress syndrome and multiple organ failure, but little is known about its pathophysiology. Here we generated single-cell atlases of...
4.
Delorey T, Ziegler C, Heimberg G, Normand R, Yang Y, Segerstolpe A, et al.
bioRxiv
. 2021 Mar;
PMID: 33655247
The SARS-CoV-2 pandemic has caused over 1 million deaths globally, mostly due to acute lung injury and acute respiratory distress syndrome, or direct complications resulting in multiple-organ failures. Little is...
5.
Roh H, Kumari M, Taleb S, Tenen D, Jacobs C, Lyubetskaya A, et al.
Mol Metab
. 2020 Sep;
42:101086.
PMID: 32992037
Objective: Obesity due to overnutrition causes adipose tissue dysfunction, which is a critical pathological step on the road to type 2 diabetes (T2D) and other metabolic disorders. In this study,...
6.
Roh H, Tsai L, Lyubetskaya A, Tenen D, Kumari M, Rosen E
Cell Rep
. 2017 Jan;
18(4):1048-1061.
PMID: 28122230
Epigenomic mechanisms direct distinct gene expression programs for different cell types. Various in vivo tissues have been subjected to epigenomic analysis; however, these studies have been limited by cellular heterogeneity,...
7.
Kang S, Tsai L, Rosen E
Trends Cell Biol
. 2016 Jan;
26(5):341-351.
PMID: 26822036
Insulin resistance is a sine qua non of type 2 diabetes and is associated with many other clinical conditions. Decades of research into mechanisms underlying insulin resistance have mostly focused...
8.
Ziller M, Gu H, Muller F, Donaghey J, Tsai L, Kohlbacher O, et al.
Nature
. 2013 Aug;
500(7463):477-81.
PMID: 23925113
DNA methylation is a defining feature of mammalian cellular identity and is essential for normal development. Most cell types, except germ cells and pre-implantation embryos, display relatively stable DNA methylation...
9.
King I, Tsai L, Pflanz R, Voigt A, Lee S, Jackle H, et al.
J Neurosci
. 2011 Jan;
31(3):1139-48.
PMID: 21248138
In both mammalian and insect models of ethanol-induced behavior, low doses of ethanol stimulate locomotion. However, the mechanisms of the stimulant effects of ethanol on the CNS are mostly unknown....
10.
Heberlein U, Tsai L, Kapfhamer D, Lasek A
Neuropharmacology
. 2008 Aug;
56 Suppl 1:97-106.
PMID: 18694769
In the last decade, the fruit fly Drosophila melanogaster, highly accessible to genetic, behavioral and molecular analyses, has been introduced as a novel model organism to help decipher the complex...