Linda M van der Graaf
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Explore the profile of Linda M van der Graaf including associated specialties, affiliations and a list of published articles.
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23
Citations
324
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Recent Articles
11.
Grand Moursel L, van Roon-Mom W, Kielbasa S, Mei H, Buermans H, van der Graaf L, et al.
Front Aging Neurosci
. 2018 May;
10:102.
PMID: 29706885
Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) is an early onset hereditary form of cerebral amyloid angiopathy (CAA) caused by a point mutation resulting in an amino acid change (NP_000475.1:p.Glu693Gln)...
12.
Buijsen R, Gardiner S, Bouma M, van der Graaf L, Boogaard M, Pepers B, et al.
Stem Cell Res
. 2018 Apr;
29:125-128.
PMID: 29656178
Spinocerebellar ataxia type 1 (SCA1) is a hereditary neurodegenerative disease caused by a CAG repeat expansion in exon 8 of the ATXN1 gene. We generated induced pluripotent stem cells (hiPSCs)...
13.
Bulk M, Abdelmoula W, Nabuurs R, van der Graaf L, Mulders C, Mulder A, et al.
Neurobiol Aging
. 2017 Dec;
62:231-242.
PMID: 29195086
Previous MRI studies reported cortical iron accumulation in early-onset (EOAD) compared to late-onset (LOAD) Alzheimer disease patients. However, the pattern and origin of iron accumulation is poorly understood. This study...
14.
Grand Moursel L, Munting L, van der Graaf L, van Duinen S, Goumans M, Ueberham U, et al.
Brain Pathol
. 2017 May;
28(4):495-506.
PMID: 28557134
Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) is an early onset hereditary form of cerebral amyloid angiopathy (CAA) pathology, caused by the E22Q mutation in the amyloid β (Aβ) peptide....
15.
Rotman M, Welling M, van den Boogaard M, Grand Moursel L, van der Graaf L, van Buchem M, et al.
Nucl Med Biol
. 2015 May;
42(8):695-702.
PMID: 25960433
Introduction: Llama single domain antibody fragments (VHH), which can pass endothelial barriers, are being investigated for targeting amyloid plaque load in Alzheimer's disease (AD). Contrary to conventional human or murine...
16.
Bison S, Pool S, Koelewijn S, van der Graaf L, Groen H, Melis M, et al.
EJNMMI Res
. 2014 Jul;
4:21.
PMID: 24995150
Background: Previously, we reported on the unexpected development of distant metastases in the subcutaneous rat pancreas CA20948 tumor model after 4.5 weeks of treatment with RAD001-only or in combination with...
17.
Segers F, den Adel B, Bot I, van der Graaf L, van der Veer E, Gonzalez W, et al.
Arterioscler Thromb Vasc Biol
. 2013 Jun;
33(8):1812-9.
PMID: 23744990
Objective: In search of molecular imaging modalities for specific detection of inflammatory atherosclerotic plaques, we explored the potential of targeting scavenger receptor-AI (SR-AI), which is highly expressed by lesional macrophages...
18.
den Adel B, van der Graaf L, Strijkers G, Lamb H, Poelmann R, van der Weerd L
PLoS One
. 2013 Mar;
8(3):e57299.
PMID: 23472079
Background: High-resolution contrast-enhanced imaging of the murine atherosclerotic vessel wall is difficult due to unpredictable flow artifacts, motion of the thin artery wall and problems with flow suppression in the...
19.
Pool S, Bison S, Koelewijn S, van der Graaf L, Melis M, Krenning E, et al.
Cancer Res
. 2012 Nov;
73(1):12-8.
PMID: 23149918
Inhibition of mTOR is commonly considered a valid target in cancer treatment, but this assertion does not address effects on the immune microenvironment that may be detrimental to cancer treatment....
20.
den Adel B, van der Graaf L, Que I, Strijkers G, Lowik C, Poelmann R, et al.
Contrast Media Mol Imaging
. 2012 Oct;
8(1):63-71.
PMID: 23109394
The use of contrast-enhanced MRI to enable in vivo specific characterization of atherosclerotic plaques is increasing. In this study the intrinsic ability of two differently sized gadolinium-based contrast agents to...