Linda M van der Graaf
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Explore the profile of Linda M van der Graaf including associated specialties, affiliations and a list of published articles.
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23
Citations
324
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Recent Articles
1.
Buijsen R, van der Graaf L, Kuijper E, Pepers B, Daoutsali E, Weel L, et al.
Biomedicines
. 2024 Sep;
12(9).
PMID: 39335447
Antisense technology demonstrates significant potential for addressing inherited brain diseases, with over a dozen products already available and numerous others in the development pipeline. The versatility of differentiating induced pluripotent...
2.
Bouwman L, Joosen M, Buijsen R, van der Graaf L, Pepers B, Voesenek B, et al.
Stem Cell Res
. 2024 Jun;
78:103462.
PMID: 38851031
Spinocerebellar Ataxia Type 7 (SCA7) is an autosomal dominantly inherited disorder, primarily characterized by cerebellar ataxia and visual loss. SCA7 is caused by a CAG repeat expansion in exon 3...
3.
Buijsen R, Hu M, Saez-Gonzalez M, Notopoulou S, Mina E, Koning W, et al.
Mov Disord
. 2023 Jun;
38(8):1428-1442.
PMID: 37278528
Background: Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disease caused by a polyglutamine expansion in the ataxin-1 protein resulting in neuropathology including mutant ataxin-1 protein aggregation, aberrant neurodevelopment, and...
4.
Daoutsali E, Pepers B, Stamatakis S, van der Graaf L, Terwindt G, Parfitt D, et al.
Front Aging Neurosci
. 2023 Feb;
14:1048584.
PMID: 36733499
Introduction: ADutch-type cerebral amyloid angiopathy (D-CAA) is a hereditary brain disorder caused by a point mutation in the amyloid precursor protein (APP) gene. The mutation is located within the amyloid...
5.
Daoutsali E, Hailu T, Buijsen R, Pepers B, van der Graaf L, Verbeek M, et al.
Nucleic Acid Ther
. 2021 Jun;
31(5):351-363.
PMID: 34061681
Dutch-type cerebral amyloid angiopathy (D-CAA) is a monogenic form of cerebral amyloid angiopathy and is inherited in an autosomal dominant manner. The disease is caused by a point mutation in...
6.
van der Graaf L, Gardiner S, Tok M, Brands T, Boogaard M, Pepers B, et al.
Stem Cell Res
. 2019 Jul;
39:101498.
PMID: 31326748
Huntington disease (HD) is an autosomal dominant, neurodegenerative disease caused by a CAG repeat expansion within the coding sequence of the HTT gene, resulting in a highly toxic protein with...
7.
Grand Moursel L, van der Graaf L, Bulk M, van Roon-Mom W, van der Weerd L
Brain Pathol
. 2019 Mar;
29(6):793-802.
PMID: 30868685
In severe forms of cerebral amyloid angiopathy (CAA) pathology, vascular calcification has been observed in the cerebral cortex, both in vivo on MRI and CT, and post-mortem using histopathology. However,...
8.
Daoutsali E, Buijsen R, van de Pas S, Jong A, Mikkers H, Brands T, et al.
Stem Cell Res
. 2019 Jan;
34:101359.
PMID: 30611017
Hereditary Cerebral Hemorrhage with Amyloidosis-Dutch type (HCHWA-D) is an autosomal dominant hereditary disease caused by a point mutation in exon 17 of the APP gene. We generated human induced pluripotent...
9.
Bulk M, Grand Moursel L, van der Graaf L, van Veluw S, Greenberg S, van Duinen S, et al.
Stroke
. 2018 Oct;
49(9):2081-2087.
PMID: 30354978
Background and Purpose- Previous studies of symptomatic and asymptomatic hereditary cerebral amyloid angiopathy (CAA) patients offered the possibility to study the radiological manifestations of CAA in the early stages of...
10.
Bulk M, Kenkhuis B, van der Graaf L, Goeman J, Natte R, van der Weerd L
J Alzheimers Dis
. 2018 Aug;
65(4):1125-1137.
PMID: 30103327
The value of iron-based MRI changes for the diagnosis and staging of Alzheimer's disease (AD) depends on an association between cortical iron accumulation and AD pathology. Therefore, this study determined...