Linda Chelico
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Explore the profile of Linda Chelico including associated specialties, affiliations and a list of published articles.
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59
Citations
1494
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Recent Articles
1.
Ara A, Love R, Follack T, Ahmed K, Adolph M, Chelico L
J Virol
. 2025 Jan;
99(2):e0220424.
PMID: 39817775
No abstract available.
2.
Gaba A, Yousefi M, Bhattacharjee S, Chelico L
J Virol
. 2024 Dec;
99(1):e0160624.
PMID: 39714157
Several APOBEC3 enzymes restrict HIV-1 by deaminating cytosine to form uracil in single-stranded proviral (-)DNA. However, HIV-1 Vif counteracts their activity by inducing their proteasomal degradation. This counteraction by Vif...
3.
Jang G, Annan Sudarsan A, Shayeganmehr A, Prando Munhoz E, Lao R, Gaba A, et al.
Mol Cell Proteomics
. 2024 Mar;
23(5):100755.
PMID: 38548018
Human APOBEC3 enzymes are a family of single-stranded (ss)DNA and RNA cytidine deaminases that act as part of the intrinsic immunity against viruses and retroelements. These enzymes deaminate cytosine to...
4.
Jang G, Annan Sudarsan A, Shayeganmehr A, Prando Munhoz E, Lao R, Gaba A, et al.
bioRxiv
. 2024 Feb;
PMID: 38370690
Human APOBEC3 enzymes are a family of single-stranded (ss)DNA and RNA cytidine deaminases that act as part of the intrinsic immunity against viruses and retroelements. These enzymes deaminate cytosine to...
5.
Cheekireddy M, Madampage C, Hammond C, Chelico L, King A
Can Commun Dis Rep
. 2023 Dec;
48(10):424-428.
PMID: 38125393
Background: In 2019, the human immunodeficiency virus (HIV) and hepatitis C (HCV) diagnosis rates in Saskatchewan (SK) were approximately twice the national rate. To address these high levels, Saskatchewan Stories,...
6.
Granadillo Rodriguez M, Wong L, Chelico L
Front Genome Ed
. 2023 Jun;
5:1196697.
PMID: 37324648
APOBEC3 (A3) enzymes deaminate cytosine to uracil in viral single-stranded DNA as a mutagenic barrier for some viruses. A3-induced deaminations can also occur in human genomes resulting in an endogenous...
7.
Yousefi M, Annan Sudarsan A, Gaba A, Chelico L
Viruses
. 2023 Feb;
15(2).
PMID: 36851677
The seven human APOBEC3 enzymes (APOBEC3A through H, excluding E) are host restriction factors. Most of the APOBEC3 enzymes can restrict HIV-1 replication with different efficiencies. The HIV-1 Vif protein...
8.
Liu W, Newhall K, Khani F, Barlow L, Nguyen D, Gu L, et al.
Cancer Res
. 2022 Dec;
83(4):506-520.
PMID: 36480186
Significance: APOBEC3G plays a role in cancer mutagenesis and clonal heterogeneity, which can potentially inform future therapeutic efforts that restrict tumor evolution. See related commentary by Caswell and Swanton, p....
9.
Wong L, Sami A, Chelico L
Nucleic Acids Res
. 2022 Nov;
50(21):12039-12057.
PMID: 36444883
The human APOBEC family of eleven cytosine deaminases use RNA and single-stranded DNA (ssDNA) as substrates to deaminate cytosine to uracil. This deamination event has roles in lipid metabolism by...
10.
Barzak F, Ryan T, Mohammadzadeh N, Harjes S, Kvach M, Kurup H, et al.
Viruses
. 2022 Sep;
14(9).
PMID: 36146779
APOBEC3 enzymes are polynucleotide deaminases, converting cytosine to uracil on single-stranded DNA (ssDNA) and RNA as part of the innate immune response against viruses and retrotransposons. APOBEC3G is a two-domain...