Linda Burkly
Overview
Explore the profile of Linda Burkly including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
532
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0
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Recent Articles
1.
Evans R, Bolduc P, Pfaffenbach M, Gao F, May-Dracka T, Fang T, et al.
J Med Chem
. 2024 Mar;
67(6):4676-4690.
PMID: 38467640
Interleukin receptor-associated kinase 4 (IRAK4) is a key node of signaling within the innate immune system that regulates the production of inflammatory cytokines and chemokines. The presence of amage-ssociated olecular...
2.
Gupta R, Gracias D, Figueroa D, Miki H, Miller J, Fung K, et al.
Sci Immunol
. 2021 Nov;
6(65):eabi8823.
PMID: 34797693
TNF and IL-17 are two cytokines that drive dysregulated keratinocyte activity, and their targeting is highly efficacious in patients with psoriasis, but whether these molecules act with other inflammatory factors...
3.
Gyoneva S, Hosur R, Gosselin D, Zhang B, Ouyang Z, Cotleur A, et al.
Life Sci Alliance
. 2019 Dec;
2(6).
PMID: 31792059
CX3CR1, one of the highest expressed genes in microglia in mice and humans, is implicated in numerous microglial functions. However, the molecular mechanisms underlying signaling are not well understood. Here,...
4.
Motwani M, Pawaria S, Bernier J, Moses S, Henry K, Fang T, et al.
Proc Natl Acad Sci U S A
. 2019 Apr;
116(16):7941-7950.
PMID: 30944222
Studies over the past decade have revealed a central role for innate immune sensors in autoimmune and autoinflammatory diseases. cGAS, a cytosolic DNA sensor, detects both foreign and host DNA...
5.
Kichev A, Baburamani A, Vontell R, Gressens P, Burkly L, Thornton C, et al.
Front Neurol
. 2018 May;
9:230.
PMID: 29706927
Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine member of the TNF family. TWEAK binds to its only known receptor, Fn14, enabling it to activate...
6.
Claus M, Herro R, Wolf D, Buscher K, Rudloff S, Huynh-Do U, et al.
Am J Transplant
. 2017 Dec;
18(7):1636-1645.
PMID: 29266762
Calcineurin inhibitor toxicity (CNT) is a frequent occurrence in transplanted renal grafts and autochthone kidneys from patients undergoing long-term treatment with calcineurin inhibitors, notably cyclosporin A (CsA) and tacrolimus. Here,...
7.
Sidler D, Wu P, Herro R, Claus M, Wolf D, Kawakami Y, et al.
Nat Commun
. 2017 May;
8:15395.
PMID: 28530223
Atopic dermatitis (AD) and psoriasis are driven by alternate type 2 and type 17 immune responses, but some proteins might be critical to both diseases. Here we show that a...
8.
Shock A, Burkly L, Wakefield I, Peters C, Garber E, Ferrant J, et al.
Arthritis Res Ther
. 2015 Sep;
17:234.
PMID: 26335795
Introduction: CD40 ligand (CD40L) blockade has demonstrated efficacy in experimental autoimmune models. However, clinical trials of hu5c8, an anti-human CD40L IgG1 antibody, in systemic lupus erythematosus (SLE) were halted due...
9.
Rapacchi S, Smith R, Wang Y, Yan L, Sigalov V, Krasileva K, et al.
Magn Reson Imaging
. 2015 Jun;
33(9):1066-1074.
PMID: 26119419
Purpose: To identify potential biomarkers of the renal impairment in lupus nephritis using a multi-parametric renal quantitative MRI (qMRI) protocol including diffusion weighted imaging (DWI), blood oxygen level dependent (BOLD),...
10.
Desplat-Jego S, Burkly L, Putterman C
Mediators Inflamm
. 2014 May;
2014:628748.
PMID: 24803741
No abstract available.