Lina Carlini
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Explore the profile of Lina Carlini including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
227
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Recent Articles
1.
Spastin regulates anaphase chromosome separation distance and microtubule-containing nuclear tunnels
Kelley M, Carlini L, Kornakov N, Aher A, Khodjakov A, Kapoor T
Mol Biol Cell
. 2024 Feb;
35(4):ar48.
PMID: 38335450
Nuclear envelope reassembly during the final stages of each mitosis depends on disassembling spindle microtubules without disrupting chromosome separation. This process involves the transient recruitment of the ESCRT-III complex and...
2.
Carlini L, Renda F, Pamula M, Khodjakov A, Kapoor T
Proc Natl Acad Sci U S A
. 2022 Sep;
119(39):e2204068119.
PMID: 36122237
Chromosome segregation requires load-bearing interactions across kinetochore fibers and antiparallel microtubule bundles, which constitute the spindle midzone. Mechanical properties of kinetochore fibers have been characterized during metaphase, when the mitotic...
3.
Renda F, Miles C, Tikhonenko I, Fisher R, Carlini L, Kapoor T, et al.
Curr Biol
. 2022 Feb;
32(5):1049-1063.e4.
PMID: 35108523
Proper segregation of chromosomes during mitosis depends on "amphitelic attachments"-load-bearing connections of sister kinetochores to the opposite spindle poles via bundles of microtubules, termed as the "K-fibers." Current models of...
4.
Mahecic D, Carlini L, Kleele T, Colom A, Goujon A, Matile S, et al.
Cell Rep
. 2021 Apr;
35(2):108947.
PMID: 33852852
During mitochondrial fission, key molecular and cellular factors assemble on the outer mitochondrial membrane, where they coordinate to generate constriction. Constriction sites can eventually divide or reverse upon disassembly of...
5.
Carlini L, Brittingham G, Holt L, Kapoor T
Dev Cell
. 2020 Aug;
54(5):574-582.e4.
PMID: 32818469
Mesoscale macromolecular complexes and organelles, tens to hundreds of nanometers in size, crowd the eukaryotic cytoplasm. It is therefore unclear how mesoscale particles remain sufficiently mobile to regulate dynamic processes...
6.
Pamula M, Carlini L, Forth S, Verma P, Suresh S, Legant W, et al.
J Cell Biol
. 2019 Jun;
218(8):2529-2544.
PMID: 31248912
In the spindle midzone, microtubules from opposite half-spindles form bundles between segregating chromosomes. Microtubule bundles can either push or restrict chromosome movement during anaphase in different cellular contexts, but how...
7.
Gerganova V, Floderer C, Archetti A, Michon L, Carlini L, Reichler T, et al.
Elife
. 2019 May;
8.
PMID: 31050340
Protein concentration gradients pattern developing organisms and single cells. In rod-shaped cells, Pom1 kinase forms gradients with maxima at cell poles. Pom1 controls the timing of mitotic entry by inhibiting...
8.
Carlini L, Holden S, Douglass K, Manley S
PLoS One
. 2015 Nov;
10(11):e0142949.
PMID: 26600467
Three-dimensional (3D) localization-based super-resolution microscopy (SR) requires correction of aberrations to accurately represent 3D structure. Here we show how a depth-dependent lateral shift in the apparent position of a fluorescent...
9.
Min J, Holden S, Carlini L, Unser M, Manley S, Ye J
Biomed Opt Express
. 2015 Nov;
5(11):3935-48.
PMID: 26526603
Localization microscopy achieves nanoscale spatial resolution by iterative localization of sparsely activated molecules, which generally leads to a long acquisition time. By implementing advanced algorithms to treat overlapping point spread...
10.
Min J, Vonesch C, Kirshner H, Carlini L, Olivier N, Holden S, et al.
Sci Rep
. 2014 Apr;
4:4577.
PMID: 24694686
Super resolution microscopy such as STORM and (F)PALM is now a well known method for biological studies at the nanometer scale. However, conventional imaging schemes based on sparse activation of...