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Lily Y J Zhang

Explore the profile of Lily Y J Zhang including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 8
Citations 260
Followers 0
Related Specialties
Neurology
Chemistry
Cell Biology
Top 10 Co-Authors
Lynn A Raymond
Jing Fan
Michael R Hayden
Liang Wang
Clare M Gladding
Jian Xu
Catherine M Cowan
Mannie M Y Fan
Paul J Lombroso
Austen J Milnerwood
Published In
J Neurosci
J Neurochem
Hum Mol Genet
Front Cell Neurosci
Neurobiol Dis
Affiliations
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Recent Articles
1.
Impairment and Restoration of Homeostatic Plasticity in Cultured Cortical Neurons From a Mouse Model of Huntington Disease
Smith-Dijak A, Nassrallah W, Zhang L, Geva M, Hayden M, Raymond L
Front Cell Neurosci . 2019 Jun; 13:209. PMID: 31156395
Huntington disease (HD) is an inherited neurodegenerative disorder caused by a mutation in the gene. The onset of symptoms is preceded by synaptic dysfunction. Homeostatic synaptic plasticity (HSP) refers to...
2.
Alterations in STriatal-Enriched protein tyrosine Phosphatase expression, activation, and downstream signaling in early and late stages of the YAC128 Huntington's disease mouse model
Gladding C, Fan J, Zhang L, Wang L, Xu J, Li E, et al.
J Neurochem . 2014 Mar; 130(1):145-59. PMID: 24588402
Striatal neurodegeneration and synaptic dysfunction in Huntington's disease are mediated by the mutant huntingtin (mHtt) protein. MHtt disrupts calcium homeostasis and facilitates excitotoxicity, in part by altering NMDA receptor (NMDAR)...
3.
Calpain and STriatal-Enriched protein tyrosine phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model
Gladding C, Sepers M, Xu J, Zhang L, Milnerwood A, Lombroso P, et al.
Hum Mol Genet . 2012 Apr; 21(17):3739-52. PMID: 22523092
In Huntington's disease (HD), the mutant huntingtin (mhtt) protein is associated with striatal dysfunction and degeneration. Excitotoxicity and early synaptic defects are attributed, in part, to altered NMDA receptor (NMDAR)...
4.
P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease
Fan J, Gladding C, Wang L, Zhang L, Kaufman A, Milnerwood A, et al.
Neurobiol Dis . 2011 Dec; 45(3):999-1009. PMID: 22198502
Huntington disease (HD) is a dominantly inherited neurodegenerative disease caused by a polyglutamine (polyQ) expansion in the protein huntingtin (htt). Previous studies have shown enhanced N-methyl-d-aspartate (NMDA)-induced excitotoxicity in neuronal...
5.
N-methyl-D-aspartate receptor subunit- and neuronal-type dependence of excitotoxic signaling through post-synaptic density 95
Fan J, Vasuta O, Zhang L, Wang L, George A, Raymond L
J Neurochem . 2010 Sep; 115(4):1045-56. PMID: 20831617
NMDA receptors (NMDARs) mediate excitatory synaptic transmission during repetitive or prolonged glutamate release, playing a critical role in synaptic plasticity or cell death, respectively. Evidence indicates that a major pathway...
6.
Interaction of postsynaptic density protein-95 with NMDA receptors influences excitotoxicity in the yeast artificial chromosome mouse model of Huntington's disease
Fan J, Cowan C, Zhang L, Hayden M, Raymond L
J Neurosci . 2009 Sep; 29(35):10928-38. PMID: 19726651
Evidence suggests that NMDA-type glutamate receptors contribute to degeneration of striatal medium-sized spiny neurons (MSNs) in Huntington's disease (HD). Previously, we demonstrated that NMDA receptor (NMDAR)-mediated current and/or toxicity is...
7.
Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: impact on NMDA receptor function and toxicity
Cowan C, Fan M, Fan J, Shehadeh J, Zhang L, Graham R, et al.
J Neurosci . 2008 Nov; 28(48):12725-35. PMID: 19036965
Huntington disease (HD), caused by CAG expansion in the ubiquitously expressed huntingtin gene, is characterized by early dysfunction and death of striatal medium-sized spiny neurons (MSNs). Previous work has shown...
8.
Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease
Fan M, Fernandes H, Zhang L, Hayden M, Raymond L
J Neurosci . 2007 Apr; 27(14):3768-79. PMID: 17409241
Overactivation of NMDA receptors (NMDARs) is believed to play a role in degeneration of striatal medium-sized spiny neurons (MSNs) in Huntington's disease (HD). This hereditary disorder is caused by an...